Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 7/20 | 0.79 |
| ▸ | AURKA | O14965 | 13/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 9/20 | 0.48 |
| ▸ | ABL1 | P00519 | 5/20 | 0.44 |
| ▸ | BCR | P11274 | 3/20 | 0.44 |
| ▸ | PLK1 | P53350 | 2/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 8/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.43 |
| ▸ | FLT3 | P36888 | 3/20 | 0.43 |
| ▸ | LIMK2 | P53671 | 2/20 | 0.43 |
| ▸ | AURKC | Q9UQB9 | 2/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.42 |
| ▸ | RET | P07949 | 4/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.42 |
| ▸ | PLK4 | O00444 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.42 |
| ▸ | LCK | P06239 | 3/20 | 0.42 |
| ▸ | FYN | P06241 | 3/20 | 0.42 |
| ▸ | LYN | P07948 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1892593 | 0.92 | IGF1R (0.82) | IGF1RAURKAAURKBABL1BCR | |
| SCHEMBL1889680 | 0.89 | IGF1R (0.87) | IGF1RAURKAAURKBABL1BCR | |
| SCHEMBL1887750 | 0.88 | IGF1R (1.00) | IGF1RAURKAAURKBABL1BCR | |
| SCHEMBL1890153 | 0.87 | IGF1R (0.75) | IGF1RAURKAAURKBABL1BCR | |
| SCHEMBL1888106 | 0.87 | IGF1R (0.90) | IGF1RAURKAAURKBABL1BCR | |
| SCHEMBL1886313 | 0.86 | IGF1R (0.62) | IGF1RAURKAAURKBABL1ALK | |
| SCHEMBL2678090 | 0.85 | IGF1R (0.60) | IGF1RAURKAAURKBABL1BCR | |
| SCHEMBL2678087 | 0.84 | IGF1R (0.59) | IGF1RAURKAAURKBABL1BCR | |
| SCHEMBL1893521 | 0.84 | IGF1R (0.89) | IGF1RAURKAAURKBABL1BCR | |
| SCHEMBL1889863 | 0.84 | ALK (0.57) | IGF1RAURKAAURKBABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110230470-A1 | SUBSTITUTED PYRAZOLO[4,3-C]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-09-22 | — | — | US | disclosed |
| US-7947686-B2 | Substituted pyrazolo[4,3-c]pyridine derivatives active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230470-A1 | SUBSTITUTED PYRAZOLO[4,3-C]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS | MAP3K3, MAP3K1, MAP3K19 | IGF1R 760/4885AURKA 332/4885AURKB 431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.