Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK2 | P51955 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14728480 | 0.86 | NEK2 (0.47) | NEK2CHRM2CHRM3TSHRL3MBTL1 | |
| SCHEMBL15371665 | 0.73 | CHRM2 (0.41) | NEK2CHRM2CHRM3TSHR | |
| SCHEMBL22886262 | 0.73 | TSHR (0.35) | NEK2CHRM2CHRM3TSHR | |
| SCHEMBL8008730 | 0.73 | CYP11B1 (0.48) | NEK2CHRM2CHRM3TSHR | |
| SCHEMBL22172286 | 0.73 | NEK2 (0.32) | NEK2TSHR | |
| SCHEMBL19534273 | 0.72 | NEK2 (0.42) | NEK2CHRM2CHRM3TSHRL3MBTL1 | |
| SCHEMBL800500 | 0.67 | CRBN (0.46) | NEK2CHRM2CHRM3 | |
| SCHEMBL16565923 | 0.67 | CYP11B1 (0.46) | NEK2TSHR | |
| SCHEMBL15721209 | 0.66 | NEK2 (0.52) | NEK2CHRM2CHRM3L3MBTL1 | |
| SCHEMBL20661569 | 0.65 | KDM4E (0.42) | CHRM2CHRM3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017095898-A1 | USES OF PYRIMIDO-PYRIMIDAZINONES TO TREAT CANCER | ASANA BIOSCIENCES, LLC (US) | 2017-06-08 | — | — | WO | disclosed |