SCHEMBL18936898

SCHEMBL18936898

Cc1ccc(C(=O)n2nc(C(C)(C)C)cc2CNC(=O)C(C)c2ccc(NS(C)(=O)=O)c(F)c2)cc1

nearest known ligand 0.77

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 16/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL287957 0.87 TRPV1 (1.00) TRPV1
SCHEMBL287511 0.85 TRPV1 (0.77) TRPV1
SCHEMBL287169 0.85 TRPV1 (0.77) TRPV1
SCHEMBL287779 0.85 TRPV1 (0.68) TRPV1
SCHEMBL287991 0.83 TRPV1 (0.79) TRPV1
SCHEMBL287992 0.83 TRPV1 (0.79) TRPV1
SCHEMBL287626 0.82 TRPV1 (0.71) TRPV1
SCHEMBL287890 0.81 TRPV1 (1.00) TRPV1
SCHEMBL287426 0.80 TRPV1 (1.00) TRPV1
SCHEMBL288061 0.80 TRPV1 (1.00) TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2427435-B1 SUBSTITUTED PHENYLUREAS AND PHENYLAMIDES AS VANILLOID RECEPTOR LIGANDS MEDIFRON DBT INC (KR) 2017-06-14 EP claimed