Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 17/20 | 0.71 |
| ▸ | JAK2 | O60674 | 16/20 | 0.70 |
| ▸ | JAK1 | P23458 | 1/20 | 0.69 |
| ▸ | TYK2 | P29597 | 1/20 | 0.69 |
| ▸ | JAK3 | P52333 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18936929 | 0.86 | SYK (0.82) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL22101952 | 0.86 | SYK (0.93) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL18936859 | 0.85 | SYK (0.76) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL14717089 | 0.85 | SYK (0.82) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL18058947 | 0.84 | SYK (0.73) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL14717273 | 0.83 | SYK (1.00) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL18936844 | 0.83 | JAK2 (0.81) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL14716645 | 0.83 | SYK (1.00) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL14716799 | 0.83 | SYK (1.00) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL14717257 | 0.82 | SYK (1.00) | SYKJAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017095898-A1 | USES OF PYRIMIDO-PYRIMIDAZINONES TO TREAT CANCER | ASANA BIOSCIENCES, LLC (US) | 2017-06-08 | — | — | WO | disclosed |