Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 5/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 6/20 | 0.37 |
| ▸ | PARP11 | Q9NR21 | 6/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | PRF1 | P14222 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.34 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12077599 | 0.93 | MAPK1 (0.48) | MAPK1MAPKAPK2PARP10PARP11KCNH2 | |
| SCHEMBL12077867 | 0.88 | MAPK1 (0.49) | MAPK1MAPKAPK2PARP10PARP11KCNH2 | |
| SCHEMBL12077231 | 0.85 | MAPK1 (0.51) | MAPK1MAPKAPK2PARP10PARP11KCNH2 | |
| SCHEMBL12495502 | 0.85 | MAPK1 (0.50) | MAPK1MAPKAPK2PARP10PARP11KCNH2 | |
| SCHEMBL12495504 | 0.82 | MAPK1 (0.41) | MAPK1MAPKAPK2PARP10PARP11KCNH2 | |
| SCHEMBL12077286 | 0.81 | MAPK1 (0.51) | MAPK1MAPKAPK2PARP10PARP11KCNH2 | |
| SCHEMBL12495167 | 0.80 | MAPK1 (0.47) | MAPK1MAPKAPK2PARP10PARP11KCNH2 | |
| SCHEMBL12077565 | 0.80 | MAPK1 (0.47) | MAPK1MAPKAPK2PARP10PARP11RIPK2 | |
| SCHEMBL12078212 | 0.80 | MAPK1 (0.54) | MAPK1MAPKAPK2PARP10PARP11KCNH2 | |
| SCHEMBL12495648 | 0.80 | MAPK1 (0.41) | MAPK1MAPKAPK2PARP10PARP11KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681206-B1 | MST1 KINASE INHIBITORS AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS INC (US) | 2017-06-14 | — | — | EP | disclosed |