Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | PARP10 | Q53GL7 | 6/20 | 0.39 |
| ▸ | PARP11 | Q9NR21 | 6/20 | 0.39 |
| ▸ | CDK4 | P11802 | 2/20 | 0.39 |
| ▸ | CCND1 | P24385 | 2/20 | 0.39 |
| ▸ | CCND3 | P30281 | 2/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | CCNH | P51946 | 1/20 | 0.39 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | PRF1 | P14222 | 2/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18937023 | 0.87 | MAPK1 (0.49) | MAPK1PARP10PARP11CDK4CCND1 | |
| SCHEMBL12094127 | 0.83 | MAPK1 (0.46) | MAPK1PARP10PARP11CDK4CCND1 | |
| SCHEMBL12495515 | 0.82 | MAPK1 (0.45) | MAPK1PARP10PARP11CDK4CCND1 | |
| SCHEMBL27157797 | 0.82 | MAPK1 (0.54) | MAPK1PARP10PARP11CDK4CCND1 | |
| SCHEMBL12496231 | 0.81 | MAPK1 (0.44) | MAPK1PARP10PARP11CDK4CCND1 | |
| SCHEMBL12077344 | 0.81 | MAPK1 (0.44) | MAPK1PARP10PARP11CDK4CCND1 | |
| SCHEMBL18937009 | 0.81 | MAPK1 (0.47) | MAPK1PARP10PARP11CDK4CCND1 | |
| SCHEMBL18937008 | 0.81 | MAPK1 (0.47) | MAPK1PARP10PARP11CDK4CCND1 | |
| SCHEMBL18937007 | 0.81 | MAPK1 (0.47) | MAPK1PARP10PARP11CDK4CCND1 | |
| SCHEMBL12077536 | 0.80 | MAP4K4 (0.45) | MAPK1PARP10PARP11CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681206-B1 | MST1 KINASE INHIBITORS AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS INC (US) | 2017-06-14 | — | — | EP | disclosed |