Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 10/20 | 0.66 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.66 |
| ▸ | CDK9 | P50750 | 8/20 | 0.66 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.66 |
| ▸ | RET | P07949 | 7/20 | 0.64 |
| ▸ | CDK1 | P06493 | 5/20 | 0.62 |
| ▸ | CDC7 | O00311 | 4/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.62 |
| ▸ | PRKACA | P17612 | 4/20 | 0.62 |
| ▸ | HIPK2 | Q9H2X6 | 4/20 | 0.62 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.62 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.62 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.62 |
| ▸ | JAK2 | O60674 | 3/20 | 0.62 |
| ▸ | INSR | P06213 | 3/20 | 0.62 |
| ▸ | PIM1 | P11309 | 3/20 | 0.62 |
| ▸ | FLT3 | P36888 | 3/20 | 0.62 |
| ▸ | GSK3B | P49841 | 3/20 | 0.62 |
| ▸ | JAK3 | P52333 | 3/20 | 0.62 |
| ▸ | ITK | Q08881 | 3/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18941192 | 0.99 | CDK2 (0.64) | CDK2CCNA2CDK9CCNT1RET | |
| SCHEMBL18941888 | 0.96 | CCNT1 (0.68) | CDK2CCNA2CDK9CCNT1RET | |
| SCHEMBL18941879 | 0.91 | CDK2 (0.66) | CDK2CCNA2CDK9CCNT1RET | |
| SCHEMBL18941254 | 0.90 | CDK2 (0.64) | CDK2CCNA2CDK9CCNT1RET | |
| SCHEMBL18941853 | 0.90 | CDK2 (0.66) | CDK2CCNA2CDK9CCNT1RET | |
| SCHEMBL18941027 | 0.90 | RET (0.64) | CDK2CCNA2CDK9CCNT1RET | |
| SCHEMBL18941892 | 0.89 | CDK2 (0.67) | CDK2CCNA2CDK9CCNT1RET | |
| SCHEMBL18941279 | 0.89 | CDK1 (0.64) | CDK2CCNA2CDK9CCNT1RET | |
| SCHEMBL18941035 | 0.89 | CDK2 (0.64) | CDK2CCNA2CDK9CCNT1RET | |
| SCHEMBL18941300 | 0.88 | CDK2 (0.66) | CDK2CCNA2CDK9CCNT1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3383875-B1 | 3-PYRIMIDINYL PYRROLO [2,3-B] PYRIDINE AS ANTICANCER AGENTS AND THE PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2022-02-09 | — | — | EP | disclosed |
| WO-2017094026-A1 | 3-PYRIMIDINYL PYRROLO [2,3-B] PYRIDINE AS NEW ANTICANCER AGENTS AND THE PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-06-08 | — | — | WO | disclosed |