Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRL | P40313 | 13/20 | 1.00 |
| ▸ | TMPRSS11D | O60235 | 7/20 | 0.95 |
| ▸ | PSMB5 | P28074 | 7/20 | 0.68 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.66 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.66 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.66 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.66 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.66 |
| ▸ | PSMD3 | O43242 | 1/20 | 0.66 |
| ▸ | CTSB | P07858 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | PSMC3 | P17980 | 1/20 | 0.66 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.66 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.66 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.66 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.66 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.66 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.66 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.66 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18942320 | 1.00 | CTRL (1.00) | CTRLTMPRSS11DPSMB5PSMB11PSMD11 | |
| SCHEMBL17452260 | 1.00 | CTRL (1.00) | CTRLTMPRSS11DPSMB5PSMB11PSMD11 | |
| SCHEMBL18942319 | 0.97 | CTRL (1.00) | CTRLTMPRSS11DPSMB5PSMB11PSMD11 | |
| SCHEMBL17452262 | 0.97 | CTRL (1.00) | CTRLTMPRSS11DPSMB5PSMB11PSMD11 | |
| SCHEMBL20431109 | 0.97 | CTRL (1.00) | CTRLTMPRSS11DPSMB5PSMB11PSMD11 | |
| SCHEMBL21954029 | 0.97 | CTRL (1.00) | CTRLTMPRSS11DPSMB5PSMB11PSMD11 | |
| SCHEMBL18942326 | 0.97 | CTRL (1.00) | CTRLTMPRSS11DPSMB5PSMB11PSMD11 | |
| SCHEMBL18942322 | 0.97 | CTRL (1.00) | CTRLTMPRSS11DPSMB5PSMB11PSMD11 | |
| SCHEMBL20431104 | 0.97 | CTRL (1.00) | CTRLTMPRSS11DPSMB5PSMB11PSMD11 | |
| SCHEMBL17452231 | 0.97 | CTRL (1.00) | CTRLTMPRSS11DPSMB5PSMB11PSMD11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10787482-B2 | Epoxyketone compounds for enzyme inhibition | Centrax International Inc. (US) | 2020-09-29 | — | — | US | disclosed |
| US-10640533-B2 | Epoxyketone compounds for enzyme inhibition | CENTRAX INTERNATIONAL, INC. (US) | 2020-05-05 | — | — | US | disclosed |
| US-20200087343-A1 | EPOXYKETONE COMPOUNDS FOR ENZYME INHIBITION | CENTRAX INTERNATIONAL, INC. (US) | 2020-03-19 | — | — | US | disclosed |
| US-20170158734-A1 | EPOXYKETONE COMPOUNDS FOR ENZYME INHIBITION | CENTRAX INTERNATIONAL, INC. (US) | 2017-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10787482-B2 | Epoxyketone compounds for enzyme inhibition | PSMD10, PSMC1, PSMB10 | CTRL 532/4885TMPRSS11D 946/4885PSMB5 13/4885 |
| US-10640533-B2 | Epoxyketone compounds for enzyme inhibition | PSMD10, PSMC1, PSMB10 | CTRL 532/4885TMPRSS11D 946/4885PSMB5 13/4885 |
| US-20170158734-A1 | EPOXYKETONE COMPOUNDS FOR ENZYME INHIBITION | PSMD10, PSMC1, PSMB10 | CTRL 532/4885TMPRSS11D 946/4885PSMB5 13/4885 |
| US-20200087343-A1 | EPOXYKETONE COMPOUNDS FOR ENZYME INHIBITION | PSMD10, PSMC1, PSMB10 | CTRL 532/4885TMPRSS11D 946/4885PSMB5 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.