Sugi Predict

Sugi Predict / Compounds / SCHEMBL1894472

SCHEMBL1894472

SCHEMBL1894472

CN1CCN(c2ccc(C(=O)Nc3n[nH]c4c3CN(S(=O)(=O)c3cc(F)cc(F)c3)CC4)c(CN3CCCC3)c2)CC1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 9/20 0.72
▸ NTRK1 P04629 3/20 0.44
▸ NTRK3 Q16288 3/20 0.44
▸ NTRK2 Q16620 2/20 0.44
▸ ALK Q9UM73 13/20 0.44
▸ INSR P06213 12/20 0.44
▸ PLK4 O00444 1/20 0.43
▸ DAPK3 O43293 1/20 0.43
▸ PRKCG P05129 1/20 0.43
▸ ROS1 P08922 1/20 0.43
▸ FER P16591 1/20 0.43
▸ LTK P29376 1/20 0.43
▸ WEE1 P30291 1/20 0.43
▸ FRK P42685 1/20 0.43
▸ MAPK8 P45983 1/20 0.43
▸ MST1R Q04912 1/20 0.43
▸ PTK2 Q05397 1/20 0.43
▸ TNK2 Q07912 1/20 0.43
▸ DYRK1B Q9Y463 1/20 0.43
▸ MAP4K5 Q9Y4K4 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1887621 0.99 IGF1R (0.71) IGF1RNTRK1NTRK3NTRK2ALK
SCHEMBL1890547 0.94 IGF1R (0.71) IGF1RNTRK1NTRK3NTRK2ALK
SCHEMBL1883762 0.89 IGF1R (0.71) IGF1RNTRK1NTRK3NTRK2ALK
SCHEMBL1895258 0.88 IGF1R (0.73) IGF1RNTRK1NTRK3NTRK2ALK
SCHEMBL1885928 0.88 IGF1R (0.81) IGF1RNTRK1NTRK3NTRK2ALK
SCHEMBL1895402 0.88 IGF1R (0.68) IGF1RNTRK1NTRK3NTRK2ALK
SCHEMBL1892764 0.88 IGF1R (0.55) IGF1RNTRK1NTRK3NTRK2ALK
SCHEMBL1885859 0.87 IGF1R (0.68) IGF1RNTRK1NTRK3NTRK2ALK
SCHEMBL2452444 0.87 IGF1R (0.54) IGF1RNTRK1NTRK3NTRK2ALK
SCHEMBL1889877 0.87 IGF1R (0.79) IGF1RNTRK1NTRK3NTRK2ALK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8173659-B2 Substituted pyrazolo[4,3-C]pyridine derivatives active as kinase inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2012-05-08 — — US disclosed
US-20110230470-A1 SUBSTITUTED PYRAZOLO[4,3-C]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2011-09-22 — — US disclosed
US-7947686-B2 Substituted pyrazolo[4,3-c]pyridine derivatives active as kinase inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2011-05-24 — — US disclosed
US-20090023745-A1 Substituted Pyrazolo[4,3-c]Pyridine Derivatives Active as Kinase Inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2009-01-22 — — US disclosed
EP-1968976-A1 SUBSTITUTED PYRAZOLO [4,3-C] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.r.l. (IT) 2008-09-17 — — EP disclosed
WO-2007068619-A1 SUBSTITUTED PYRAZOLO [4,3-C] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2007-06-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110230470-A1 SUBSTITUTED PYRAZOLO[4,3-C]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS MAP3K3, MAP3K1, MAP3K19 IGF1R 760/4885NTRK1 1131/4885NTRK3 925/4885
US-20090023745-A1 Substituted Pyrazolo[4,3-c]Pyridine Derivatives Active as Kinase Inhibitors MAP3K3, MAP3K1, MAP3K19 IGF1R 760/4885NTRK1 1131/4885NTRK3 925/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.