SCHEMBL18947665

SCHEMBL18947665

Cc1ccc(-c2c(-c3ccccc3)c(-c3ccccc3)c(-c3ccc(C)c(C(F)(F)F)c3)c3ccccc23)cc1C

nearest known ligand 0.49

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 3/20 0.49
ESR1 P03372 1/20 0.39
PTGS2 P35354 2/20 0.39
NOTUM Q6P988 1/20 0.38
NR1H2 P55055 5/20 0.38
NR1H3 Q13133 4/20 0.38
AR P10275 2/20 0.37
TAS2R14 Q9NYV8 1/20 0.36
PDE3B Q13370 1/20 0.36
PDE3A Q14432 1/20 0.36
RORC P51449 1/20 0.35
ENPP1 P22413 2/20 0.35
MEN1 O00255 1/20 0.34
ALDH1A1 P00352 1/20 0.34
LMNA P02545 1/20 0.34
MAPT P10636 1/20 0.34
MAPK1 P28482 1/20 0.34
KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18947657 0.96 S1PR1 (0.48) S1PR1ESR1PTGS2NOTUMNR1H2
SCHEMBL18948612 0.95 S1PR1 (0.52) S1PR1ESR1NOTUMNR1H2NR1H3
SCHEMBL18948603 0.91 S1PR1 (0.51) S1PR1ESR1NOTUMNR1H2NR1H3
SCHEMBL18947655 0.91 S1PR1 (0.47) S1PR1ESR1PTGS2NOTUMNR1H2
SCHEMBL18947647 0.89 S1PR1 (0.52) S1PR1ESR1NOTUMNR1H2AR
SCHEMBL18947650 0.89 S1PR1 (0.46) S1PR1ESR1PTGS2NOTUMNR1H2
SCHEMBL18947654 0.88 S1PR1 (0.45) S1PR1ESR1PTGS2NOTUMNR1H2
SCHEMBL18947661 0.88 S1PR1 (0.45) S1PR1ESR1PTGS2NOTUMNR1H2
SCHEMBL18948623 0.86 S1PR1 (0.50) S1PR1ESR1NOTUMNR1H2NR1H3
SCHEMBL18948634 0.85 S1PR1 (0.44) S1PR1ESR1NOTUMNR1H2NR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9676906-B1 Polymer of poly(arylene ether)s, manufacturing method thereof and polymer light emitting diode with organic light emitting layer made from the same NATIONAL SUN YAT-SEN UNIVERSITY (TW) 2017-06-13 US disclosed