Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 18/20 | 0.83 |
| ▸ | PRKDC | P78527 | 1/20 | 0.83 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10142608 | 1.00 | PIK3CG (0.83) | PIK3CGPRKDCPIK3CDPIK3CALRRK2 | |
| SCHEMBL18948408 | 1.00 | PIK3CG (0.83) | PIK3CGPRKDCPIK3CDPIK3CALRRK2 | |
| SCHEMBL10142650 | 0.91 | PIK3CG (1.00) | PIK3CGPRKDCPIK3CDPIK3CALRRK2 | |
| SCHEMBL10142647 | 0.91 | PIK3CG (1.00) | PIK3CGPRKDCPIK3CDPIK3CALRRK2 | |
| SCHEMBL612044 | 0.91 | PIK3CG (1.00) | PIK3CGPRKDCPIK3CDPIK3CALRRK2 | |
| SCHEMBL10142787 | 0.90 | PIK3CG (0.83) | PIK3CGPRKDCPIK3CDPIK3CAADORA2A | |
| SCHEMBL612092 | 0.90 | PIK3CG (0.83) | PIK3CGPRKDCPIK3CDPIK3CAADORA2A | |
| SCHEMBL10142763 | 0.90 | PIK3CG (0.83) | PIK3CGPRKDCPIK3CDPIK3CAADORA2A | |
| SCHEMBL10142614 | 0.89 | PIK3CG (0.82) | PIK3CGPRKDCPIK3CDPIK3CALRRK2 | |
| SCHEMBL10142483 | 0.89 | PIK3CG (0.82) | PIK3CGPRKDCPIK3CDPIK3CALRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9676759-B2 | Isoindolinone inhibitors of phosphatidylinositol 3-kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2017-06-13 | — | — | US | disclosed |