Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 9/20 | 0.41 |
| ▸ | BLM | P54132 | 7/20 | 0.41 |
| ▸ | LMNA | P02545 | 6/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.41 |
| ▸ | RECQL | P46063 | 7/20 | 0.41 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.41 |
| ▸ | THPO | P40225 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | APEX1 | P27695 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8493378 | 0.79 | CA12 (0.47) | TDP1BLMLMNAADRA1ANR1I2 | |
| SCHEMBL5846643 | 0.79 | GBA1 (0.41) | LMNAKMT2ACYP2C19 | |
| SCHEMBL5845490 | 0.79 | GBA1 (0.41) | LMNAKMT2ACYP2C19 | |
| SCHEMBL13395908 | 0.77 | TDP1 (0.49) | TDP1BLMLMNAADRA1ANR1I2 | |
| SCHEMBL4965778 | 0.75 | TDP1 (0.54) | TDP1BLMLMNAADRA1ANR1I2 | |
| SCHEMBL27681258 | 0.75 | TDP1 (0.54) | TDP1BLMLMNAADRA1ANR1I2 | |
| SCHEMBL8289998 | 0.75 | TDP1 (0.54) | TDP1BLMLMNAADRA1ANR1I2 | |
| SCHEMBL17599121 | 0.72 | TDP1 (0.44) | TDP1BLMLMNAADRA1ANR1I2 | |
| SCHEMBL7947871 | 0.70 | ESR1 (0.56) | TDP1BLMLMNAADRA1ANR1I2 | |
| SCHEMBL17761381 | 0.70 | TDP1 (0.49) | TDP1BLMLMNAADRA1ANR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2515876-A2 | PHARMACEUTICAL COMPOSITIONS AND ORAL DOSAGE FORMS OF A LEVODOPA PRODRUG AND METHODS OF USE | XenoPort, Inc. (US) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011056240-A2 | PHARMACEUTICAL COMPOSITIONS AND ORAL DOSAGE FORMS OF A LEVODOPA PRODRUG AND METHODS OF USE | XENOPORT, INC. (US) | 2011-05-12 | — | — | WO | disclosed |