Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.68 |
| ▸ | ERBB2 | P04626 | 12/20 | 0.68 |
| ▸ | SRC | P12931 | 2/20 | 0.68 |
| ▸ | KDR | P35968 | 2/20 | 0.68 |
| ▸ | STK3 | Q13188 | 3/20 | 0.63 |
| ▸ | STK4 | Q13043 | 3/20 | 0.63 |
| ▸ | BTK | Q06187 | 2/20 | 0.63 |
| ▸ | STK25 | O00506 | 1/20 | 0.63 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.63 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.63 |
| ▸ | GAK | O14976 | 1/20 | 0.63 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.63 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.63 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.63 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.63 |
| ▸ | STK17B | O94768 | 1/20 | 0.63 |
| ▸ | STK10 | O94804 | 1/20 | 0.63 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.63 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.63 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19223022 | 0.91 | EGFR (0.64) | EGFRERBB2SRCKDRSTK3 | |
| SCHEMBL18933592 | 0.91 | EGFR (0.71) | EGFRERBB2SRCKDRSTK3 | |
| SCHEMBL15222044 | 0.91 | EGFR (0.71) | EGFRERBB2SRCKDRSTK3 | |
| SCHEMBL18949485 | 0.90 | EGFR (0.64) | EGFRERBB2ERBB4 | |
| SCHEMBL18949418 | 0.88 | EGFR (0.65) | EGFRERBB2SRCKDRSTK3 | |
| SCHEMBL14864932 | 0.88 | EGFR (0.76) | EGFRERBB2SRCKDRSTK3 | |
| SCHEMBL18933462 | 0.86 | EGFR (0.72) | EGFRERBB2SRCKDRSTK3 | |
| SCHEMBL14854630 | 0.86 | EGFR (0.72) | EGFRERBB2SRCKDRSTK3 | |
| SCHEMBL14864935 | 0.84 | EGFR (0.70) | EGFRERBB2SRCKDRSTK3 | |
| SCHEMBL14854935 | 0.84 | EGFR (0.73) | EGFRERBB2SRCKDRSTK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9676724-B2 | Cyanoquinoline derivatives | TIANJIN HEMAY ONCOLOGY PHARMACEUTICAL CO., LTD. (CN) | 2017-06-13 | — | — | US | disclosed |