Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 15/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL161433 | 0.88 | NAMPT (0.69) | NAMPT | |
| SCHEMBL18949529 | 0.86 | NAMPT (0.64) | NAMPTALDH1A1HPGDMAPTL3MBTL1 | |
| SCHEMBL15372334 | 0.85 | NAMPT (0.63) | NAMPTALDH1A1HPGDMAPTL3MBTL1 | |
| SCHEMBL18949502 | 0.84 | NAMPT (0.69) | NAMPTALDH1A1 | |
| SCHEMBL18949639 | 0.83 | NAMPT (0.70) | NAMPT | |
| SCHEMBL18949581 | 0.80 | NAMPT (0.70) | NAMPTCYP2C9CYP2C19 | |
| SCHEMBL18949594 | 0.79 | NAMPT (0.62) | NAMPT | |
| SCHEMBL18949584 | 0.79 | NAMPT (0.62) | NAMPT | |
| SCHEMBL18949571 | 0.79 | NAMPT (0.61) | NAMPT | |
| SCHEMBL18973077 | 0.78 | NAMPT (0.65) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9676721-B2 | Compounds and compositions for the inhibition of NAMPT | FORMA TM, LLC (US) | 2017-06-13 | — | — | US | disclosed |