SCHEMBL18950883

SCHEMBL18950883

CC1CN(c2ccc3c(n2)NC(=O)CO3)C(=O)O1

nearest known ligand 0.61

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NR3C2 P08235 6/20 0.61
NR3C1 P04150 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26233765 0.85 NR3C2 (0.55) NR3C2
SCHEMBL19510094 0.82 NR3C2 (0.57) NR3C2
SCHEMBL592055 0.82 KCNH2 (0.55) NR3C2
SCHEMBL30366330 0.82 NR3C2 (0.57) NR3C2
SCHEMBL30047309 0.82 KCNH2 (0.55) NR3C2
SCHEMBL592054 0.82 KCNH2 (0.55) NR3C2
SCHEMBL21428592 0.82 NR3C2 (0.57) NR3C2
SCHEMBL21428593 0.82 KCNH2 (0.55) NR3C2
SCHEMBL21820228 0.82 NR3C2 (0.57) NR3C2
SCHEMBL30365736 0.82 KCNH2 (0.55) NR3C2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9850256-B2 Antibacterial basic biaromatic derivatives with aminoalkoxy substitution IDORSIA PHARMACEUTICALS LTD (CH) 2017-12-26 US disclosed
EP-2986607-B1 ANTIBACTERIAL BIAROMATIC DERIVATIVES ACTELION PHARMACEUTICALS LTD (CH) 2017-06-14 EP disclosed