Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ANO1 | Q5XXA6 | 5/20 | 0.41 |
| ▸ | ANO2 | Q9NQ90 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.38 |
| ▸ | PTPRC | P08575 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | PTPA | Q15257 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 2/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1895152 | 0.92 | ANO1 (0.49) | ANO1ANO2CASP3SENP8SENP7 | |
| SCHEMBL1952999 | 0.84 | ANO1 (0.55) | TP53ANO1ANO2CASP3SENP8 | |
| SCHEMBL1954120 | 0.84 | ANO1 (0.57) | ANO1ANO2CASP3SENP8SENP7 | |
| SCHEMBL1906928 | 0.78 | ANO1 (0.56) | MAPTANO1CASP3SENP8SENP7 | |
| SCHEMBL1954212 | 0.77 | ANO1 (0.55) | ANO1ANO2CASP3SENP8SENP7 | |
| SCHEMBL1954043 | 0.77 | ANO1 (0.62) | ANO1ANO2 | |
| SCHEMBL1951506 | 0.77 | ANO1 (0.67) | ANO1ANO2 | |
| SCHEMBL1907488 | 0.76 | ANO1 (0.58) | ANO1ANO2CASP3SENP8SENP7 | |
| SCHEMBL1897215 | 0.76 | MEN1 (0.53) | ANO1CASP3SENP8SENP7SENP6 | |
| SCHEMBL12271570 | 0.75 | MEN1 (0.57) | ANO1CASP3SENP8SENP7SENP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321303-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | Calcimedica, Inc. (US) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010027875-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC. (US) | 2010-03-11 | — | — | WO | disclosed |