Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18953366 | 0.91 | CXCR2 (0.49) | CXCR2NPC1HTTALDH1A1MAPT | |
| SCHEMBL18953334 | 0.91 | CXCR2 (0.44) | CXCR2NPC1HTTALDH1A1MAPT | |
| SCHEMBL18953652 | 0.91 | CXCR2 (0.42) | CXCR2NPC1HTTALDH1A1MAPT | |
| SCHEMBL18953352 | 0.90 | CXCR2 (0.50) | CXCR2NPC1HTTALDH1A1MAPT | |
| SCHEMBL18953566 | 0.90 | CXCR2 (0.61) | CXCR2NPC1HTTALDH1A1MAPT | |
| SCHEMBL18953455 | 0.90 | CXCR2 (0.43) | CXCR2NPC1HTTALDH1A1MAPT | |
| SCHEMBL18953374 | 0.90 | CXCR2 (0.43) | CXCR2NPC1HTTALDH1A1MAPT | |
| SCHEMBL18953491 | 0.87 | CXCR2 (0.46) | CXCR2NPC1HTTALDH1A1MAPT | |
| SCHEMBL18953559 | 0.87 | CXCR2 (0.40) | CXCR2NPC1MAPTPOLBLMNA | |
| SCHEMBL18953404 | 0.85 | CXCR2 (0.45) | CXCR2NPC1HTTALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017098421-A1 | BENZOTHIADIAZINE COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-06-15 | — | — | WO | claimed |
| WO-2017098421-A1 | BENZOTHIADIAZINE COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-06-15 | — | — | WO | disclosed |