Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.78 |
| ▸ | CSNK1D | P48730 | 7/20 | 0.78 |
| ▸ | CSNK1E | P49674 | 7/20 | 0.78 |
| ▸ | RAF1 | P04049 | 2/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | BRAF | P15056 | 2/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.54 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.54 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.54 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18960500 | 0.88 | MAPK14 (0.83) | MAPK14CSNK1DCSNK1ERAF1ALOX5 | |
| SCHEMBL17002188 | 0.88 | MAPK14 (1.00) | MAPK14CSNK1DCSNK1ERAF1ALOX5 | |
| SCHEMBL17002187 | 0.87 | MAPK14 (1.00) | MAPK14CSNK1DCSNK1ERAF1ALOX5 | |
| SCHEMBL17002180 | 0.85 | MAPK14 (1.00) | MAPK14CSNK1DCSNK1ERAF1ALOX5 | |
| SCHEMBL18960503 | 0.84 | MAPK14 (0.83) | MAPK14CSNK1DCSNK1ERAF1BRAF | |
| SCHEMBL17002319 | 0.83 | MAPK14 (1.00) | MAPK14CSNK1DCSNK1ERAF1ALOX5 | |
| SCHEMBL18960539 | 0.81 | MAPK14 (0.77) | MAPK14CSNK1DCSNK1ERAF1ALOX5 | |
| SCHEMBL18960502 | 0.81 | MAPK14 (0.84) | MAPK14CSNK1DCSNK1ERAF1ALOX5 | |
| SCHEMBL18966276 | 0.81 | MAPK14 (1.00) | MAPK14CSNK1DCSNK1ERAF1ALOX5 | |
| SCHEMBL17002185 | 0.81 | MAPK14 (0.72) | MAPK14CSNK1DCSNK1ERAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170166867-A1 | 2,4,5-TRI-SUBSTITUTED AZOLE-BASED CASEIN KINASE 1 INHIBITORS AS INDUCERS FOR CARDIOMYOGENESIS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2017-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170166867-A1 | 2,4,5-TRI-SUBSTITUTED AZOLE-BASED CASEIN KINASE 1 INHIBITORS AS INDUCERS FOR CARDIOMYOGENESIS | CSNK1A1, CSNK1G1, CSNK2A1 | MAPK14 241/4885CSNK1D 11/4885CSNK1E 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.