Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 20/20 | 0.67 |
| ▸ | MST1 | P26927 | 1/20 | 0.53 |
| ▸ | STK4 | Q13043 | 1/20 | 0.53 |
| ▸ | STK3 | Q13188 | 1/20 | 0.53 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15401532 | 0.80 | LRRK2 (1.00) | LRRK2MST1STK4STK3STK26 | |
| SCHEMBL15401962 | 0.76 | LRRK2 (1.00) | LRRK2MST1STK4STK3STK26 | |
| SCHEMBL15401686 | 0.76 | LRRK2 (0.69) | LRRK2MST1STK4STK3STK26 | |
| SCHEMBL18967270 | 0.76 | LRRK2 (0.69) | LRRK2MST1STK4STK3STK26 | |
| SCHEMBL15401054 | 0.76 | LRRK2 (0.70) | LRRK2MST1STK4STK3STK26 | |
| SCHEMBL15401159 | 0.73 | LRRK2 (1.00) | LRRK2MST1STK4STK3STK26 | |
| SCHEMBL15401685 | 0.72 | LRRK2 (1.00) | LRRK2MST1STK4STK3STK26 | |
| SCHEMBL15401196 | 0.71 | LRRK2 (1.00) | LRRK2MST1STK4STK3STK26 | |
| SCHEMBL15401498 | 0.70 | LRRK2 (1.00) | LRRK2MST1STK4STK3STK26 | |
| SCHEMBL15401845 | 0.70 | LRRK2 (1.00) | LRRK2MST1STK4STK3STK26 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2867236-B1 | NOVEL 4-(SUBSTITUTED-AMINO)-7H-PYRROLO[2,3-D]PYRIMIDINES AS LRRK2 INHIBITORS | PFIZER (US) | 2017-06-14 | — | — | EP | disclosed |