Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 20/20 | 1.00 |
| ▸ | STK4 | Q13043 | 1/20 | 0.64 |
| ▸ | STK3 | Q13188 | 1/20 | 0.64 |
| ▸ | JAK2 | O60674 | 1/20 | 0.61 |
| ▸ | JAK1 | P23458 | 1/20 | 0.61 |
| ▸ | JAK3 | P52333 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15402055 | 1.00 | LRRK2 (1.00) | LRRK2STK4STK3JAK2JAK1 | |
| SCHEMBL15401331 | 0.86 | LRRK2 (1.00) | LRRK2STK3JAK2JAK1JAK3 | |
| SCHEMBL15401308 | 0.83 | LRRK2 (1.00) | LRRK2JAK2JAK1JAK3 | |
| SCHEMBL18967685 | 0.83 | LRRK2 (1.00) | LRRK2JAK2JAK1JAK3 | |
| SCHEMBL18967276 | 0.81 | LRRK2 (1.00) | LRRK2JAK2JAK1JAK3 | |
| SCHEMBL15400768 | 0.81 | LRRK2 (1.00) | LRRK2JAK2JAK1JAK3 | |
| SCHEMBL15401761 | 0.80 | LRRK2 (1.00) | LRRK2JAK2JAK1JAK3 | |
| SCHEMBL18967757 | 0.80 | LRRK2 (0.67) | LRRK2JAK2JAK1JAK3 | |
| SCHEMBL18967632 | 0.79 | KHK (0.71) | LRRK2JAK2JAK1JAK3 | |
| SCHEMBL15401385 | 0.79 | LRRK2 (1.00) | LRRK2JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2867236-B1 | NOVEL 4-(SUBSTITUTED-AMINO)-7H-PYRROLO[2,3-D]PYRIMIDINES AS LRRK2 INHIBITORS | PFIZER (US) | 2017-06-14 | — | — | EP | disclosed |