Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.50 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.47 |
| ▸ | NT5E | P21589 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31067161 | 0.84 | TAAR1 (0.53) | TAAR1ESR2TNKS2NT5ECYP17A1 | |
| SCHEMBL20898196 | 0.84 | TAAR1 (0.53) | TAAR1ESR2TNKS2NT5ECYP17A1 | |
| SCHEMBL30116872 | 0.84 | TAAR1 (0.53) | TAAR1ESR2TNKS2NT5ECYP17A1 | |
| SCHEMBL31272856 | 0.82 | AHR (0.61) | TAAR1ESR2TNKS2NT5ECYP17A1 | |
| SCHEMBL18970438 | 0.82 | TAAR1 (0.55) | TAAR1ESR2TNKS2ACHEPGR | |
| SCHEMBL4300888 | 0.81 | AHR (0.55) | ESR2PTGS2PTGS1CYP3A4HPGD | |
| SCHEMBL18970412 | 0.80 | TAAR1 (0.53) | TAAR1ESR2TNKS2ACHEPTGS2 | |
| SCHEMBL308031 | 0.79 | ESR2 (0.52) | ESR2TNKS2PTGS2PTGS1CYP3A4 | |
| SCHEMBL18970517 | 0.78 | TAAR1 (0.50) | TAAR1ESR2TNKS2ACHEPGR | |
| SCHEMBL18970556 | 0.78 | TAAR1 (0.50) | TAAR1ESR2TNKS2ACHEPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2755944-B1 | BIARYLDERIVATIVES,THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI SA (FR) | 2017-06-14 | — | — | EP | disclosed |