Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 18/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 18/20 | 0.45 |
| ▸ | JAK2 | O60674 | 17/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18970844 | 0.82 | PSEN1 (0.52) | JAK3PTK2JAK2 | |
| SCHEMBL22428659 | 0.74 | PSEN1 (0.41) | JAK3PTK2JAK2 | |
| SCHEMBL22916557 | 0.71 | PSEN1 (0.52) | JAK3PTK2JAK2 | |
| SCHEMBL18970855 | 0.69 | PSEN1 (0.66) | JAK3PTK2JAK2 | |
| SCHEMBL18970917 | 0.69 | PSEN1 (0.66) | JAK3PTK2JAK2 | |
| SCHEMBL21726900 | 0.69 | PSEN1 (0.65) | JAK3PTK2JAK2 | |
| SCHEMBL18970963 | 0.69 | PSEN1 (0.65) | JAK3PTK2JAK2 | |
| SCHEMBL18971419 | 0.68 | PSEN1 (0.51) | JAK3PTK2JAK2 | |
| SCHEMBL18636423 | 0.68 | JAK3 (0.53) | JAK3PTK2JAK2 | |
| SCHEMBL18970467 | 0.67 | PSEN1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017097728-A1 | BRIDGED PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-15 | — | — | WO | disclosed |