Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 20/20 | 0.74 |
| ▸ | SLC6A4 | P31645 | 20/20 | 0.74 |
| ▸ | SLC6A3 | Q01959 | 20/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 12/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1898867 | 1.00 | SLC6A2 (0.74) | SLC6A2SLC6A4SLC6A3CYP3A4CYP2D6 | |
| SCHEMBL17455346 | 0.85 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP3A4CYP2D6 | |
| SCHEMBL17471759 | 0.85 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP3A4CYP2D6 | |
| SCHEMBL1898584 | 0.84 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP3A4CYP2D6 | |
| SCHEMBL17472328 | 0.84 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP3A4CYP2D6 | |
| SCHEMBL12004648 | 0.84 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP3A4CYP2D6 | |
| SCHEMBL17455448 | 0.84 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP3A4CYP2D6 | |
| SCHEMBL1903870 | 0.84 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP3A4CYP2D6 | |
| SCHEMBL1903873 | 0.84 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP3A4CYP2D6 | |
| SCHEMBL1897214 | 0.84 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011056773-A2 | INHIBITING NEUROTRANSMITTER REUPTAKE | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2011-05-12 | — | — | WO | claimed |
| WO-2011056788-A2 | INHIBITING NEUROTRANSMITTER REUPTAKE | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2011-05-12 | — | — | WO | claimed |
| US-20120220665-A1 | Inhibiting Neurotransmitter Reuptake | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2012-08-30 | — | — | US | disclosed |