Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 5/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | THPO | P40225 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2729020 | 1.00 | HIF1A (0.56) | HIF1ACYP3A4ALOX15PTGS1ALDH1A1 | |
| SCHEMBL2729059 | 1.00 | HIF1A (0.56) | HIF1ACYP3A4ALOX15PTGS1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28269560 | 0.98 | HIF1A (0.55) | HIF1ACYP3A4ALOX15PTGS1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28267943 | 0.98 | HIF1A (0.55) | HIF1ACYP3A4ALOX15PTGS1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28269559 | 0.98 | HIF1A (0.55) | HIF1ACYP3A4ALOX15PTGS1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28267946 | 0.98 | HIF1A (0.55) | HIF1ACYP3A4ALOX15PTGS1ALDH1A1 | |
| SCHEMBL5024993 | 0.91 | HIF1A (0.54) | HIF1ACYP3A4ALOX15PTGS1ALDH1A1 | |
| SCHEMBL28673374 | 0.91 | HIF1A (0.54) | HIF1ACYP3A4ALOX15PTGS1ALDH1A1 | |
| SCHEMBL12674441 | 0.86 | SLC7A5 (0.57) | HIF1ACYP3A4ALOX15PTGS1ALDH1A1 | |
| SCHEMBL1070680 | 0.86 | SLC7A5 (0.57) | HIF1ACYP3A4ALOX15PTGS1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109142552-B | Photolytic impurity of melphalan and salt thereof and HPLC (high performance liquid chromatography) detection method thereof | 先声药业有限公司 | 2022-07-01 | — | — | CN | disclosed |
| CN-109142552-A | The photodissociation impurity and its HPLC detection method of a kind of melphalan and its salt | 南京先声东元制药有限公司 | 2019-01-04 | — | — | CN | disclosed |
| WO-2012058325-A1 | COMPOUNDS AND METHODS USEFUL FOR TREATMENT OF DISEASES MEDIATED BY HIF-1 | ONCOTHYREON INC. (US) | 2012-05-03 | — | — | WO | disclosed |
| WO-2012058325-A1 | COMPOUNDS AND METHODS USEFUL FOR TREATMENT OF DISEASES MEDIATED BY HIF-1 | ONCOTHYREON INC. (US) | 2012-05-03 | — | — | WO | disclosed |
| WO-2011057220-A2 | COMPOSITIONS AND METHODS FOR TREATING LYMPHOMA | NORTHWESTERN UNIVERSITY (US) | 2011-05-12 | — | — | WO | disclosed |
| WO-2011057220-A2 | COMPOSITIONS AND METHODS FOR TREATING LYMPHOMA | NORTHWESTERN UNIVERSITY (US) | 2011-05-12 | — | — | WO | disclosed |