Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 16/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 2/20 | 0.31 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1896175 | 0.88 | MTOR (0.41) | MTORPIK3CAPIK3CDPDE4DATR | |
| SCHEMBL1611450 | 0.85 | MTOR (0.41) | MTORPIK3CAPIK3CDPDE4DATR | |
| SCHEMBL1611447 | 0.85 | MTOR (0.41) | MTORPIK3CAPIK3CDPDE4DATR | |
| SCHEMBL1612056 | 0.84 | MTOR (0.42) | MTORPIK3CAPIK3CDPDE4DATR | |
| SCHEMBL1612053 | 0.84 | MTOR (0.42) | MTORPIK3CAPIK3CDPDE4DATR | |
| SCHEMBL1612539 | 0.81 | MTOR (0.41) | MTORPIK3CAPIK3CDPDE4DATR | |
| SCHEMBL1612540 | 0.81 | MTOR (0.41) | MTORPIK3CAPIK3CDPDE4DATR | |
| SCHEMBL1612580 | 0.80 | MTOR (0.42) | MTORPIK3CAPIK3CDPDE4DATR | |
| SCHEMBL1612578 | 0.80 | MTOR (0.42) | MTORPIK3CAPIK3CDPDE4DATR | |
| SCHEMBL25279339 | 0.78 | MTOR (0.45) | MTORPIK3CAPIK3CDPDE4DATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2498780-A2 | N-9-SUBSTITUTED PURINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. Hoffmann-La Roche AG (CH) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011058027-A2 | N-9-SUBSTITUTED PURINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2011-05-19 | — | — | WO | disclosed |