Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.71 |
| ▸ | JAK2 | O60674 | 4/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | SRC | P12931 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | TEC | P42680 | 1/20 | 0.58 |
| ▸ | TXK | P42681 | 1/20 | 0.58 |
| ▸ | BLK | P51451 | 1/20 | 0.58 |
| ▸ | BMX | P51813 | 1/20 | 0.58 |
| ▸ | CD69 | Q07108 | 1/20 | 0.58 |
| ▸ | ITK | Q08881 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18976255 | 0.89 | BTK (0.78) | BTKJAK2LCKCYP3A4CYP2C8 | |
| SCHEMBL18976039 | 0.86 | BTK (0.69) | BTKJAK2LCKCYP3A4CYP2C8 | |
| SCHEMBL20327794 | 0.85 | BTK (0.69) | BTKJAK2LCKCYP3A4CYP2C8 | |
| SCHEMBL21509096 | 0.83 | BTK (0.79) | BTKJAK2LCKCYP3A4CYP2C8 | |
| SCHEMBL19715397 | 0.83 | BTK (1.00) | BTKJAK2 | |
| SCHEMBL20304002 | 0.82 | BTK (0.72) | BTKJAK2LCKCYP3A4CYP2C8 | |
| SCHEMBL29785259 | 0.82 | BTK (0.72) | BTKJAK2LCKCYP3A4CYP2C8 | |
| SCHEMBL20327779 | 0.82 | BTK (0.72) | BTKJAK2LCKCYP3A4CYP2C8 | |
| SCHEMBL22837855 | 0.81 | BTK (0.69) | BTKJAK2LCKCYP3A4CYP2C8 | |
| SCHEMBL18976056 | 0.81 | BTK (0.78) | BTKJAK2LCKCYP3A4CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3013814-B1 | SUBSTITUTED TETRAHYDROCARBAZOLE AND CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-06-14 | — | — | EP | disclosed |