SCHEMBL18979237

SCHEMBL18979237

O=C(O)c1ccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ADRB3 P13945 18/20 1.00
ADRB1 P08588 7/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6133635 0.99 ADRB3 (0.98) ADRB3ADRB1
Hydrochloric Acid SCHEMBL6133637 0.99 ADRB3 (0.98) ADRB3ADRB1
Hydrochloric Acid SCHEMBL6135317 0.94 ADRB3 (0.88) ADRB3ADRB1
Hydrochloric Acid SCHEMBL6135323 0.94 ADRB3 (0.88) ADRB3ADRB1
Hydrochloric Acid SCHEMBL6135200 0.93 ADRB3 (0.98) ADRB3ADRB1
Hydrochloric Acid SCHEMBL6135197 0.93 ADRB3 (0.98) ADRB3ADRB1
SCHEMBL6133871 0.90 ADRB3 (0.84) ADRB3ADRB1
Hydrochloric Acid SCHEMBL6592816 0.90 ADRB3 (0.86) ADRB3ADRB1
Hydrochloric Acid SCHEMBL6135629 0.90 ADRB3 (0.86) ADRB3ADRB1
Hydrochloric Acid SCHEMBL6135623 0.90 ADRB3 (0.86) ADRB3ADRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2531486-B1 NOVEL PROCESS FOR THE PREPARATION OF NITROGEN SUBSTITUTED AMINOTETRALINS DERIVATIVES UCB BIOPHARMA SPRL (BE) 2017-06-21 EP disclosed