Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 9/20 | 0.87 |
| ▸ | LMNA | P02545 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | GLA | P06280 | 2/20 | 0.55 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | UBE2I | P63279 | 2/20 | 0.54 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.54 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.54 |
| ▸ | SAE1 | Q9UBE0 | 2/20 | 0.54 |
| ▸ | UBA2 | Q9UBT2 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1899809 | 0.93 | STAT3 (1.00) | STAT3LMNAKDM4EMEN1KMT2A | |
| SCHEMBL29382140 | 0.93 | STAT3 (1.00) | STAT3LMNAKDM4EMEN1KMT2A | |
| SCHEMBL1897879 | 0.92 | STAT3 (0.77) | STAT3LMNAKDM4EMEN1KMT2A | |
| SCHEMBL1899563 | 0.92 | STAT3 (0.89) | STAT3LMNAKDM4EMEN1KMT2A | |
| SCHEMBL1898201 | 0.91 | STAT3 (0.81) | STAT3LMNAKDM4EMEN1KMT2A | |
| SCHEMBL1899309 | 0.91 | STAT3 (0.87) | STAT3LMNAKDM4EMEN1KMT2A | |
| SCHEMBL1898648 | 0.91 | STAT3 (0.87) | STAT3LMNAKDM4EMEN1KMT2A | |
| SCHEMBL1898205 | 0.91 | STAT3 (0.87) | STAT3LMNAKDM4EMEN1KMT2A | |
| SCHEMBL1900902 | 0.91 | STAT3 (0.87) | STAT3LMNAKDM4EMEN1KMT2A | |
| SCHEMBL1899540 | 0.90 | STAT3 (0.89) | STAT3LMNAKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220218693-A1 | IMMUNE CHECKPOINT INHIBITOR COMBINATION THERAPY USING QUINOLINE CARBOXAMIDE DERIVATIVE | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2022-07-14 | — | — | US | disclosed |
| EP-3960199-A1 | IMMUNE CHECKPOINT INHIBITOR COMBINATION THERAPY USING QUINOLINE CARBOXAMIDE DERIVATIVE | Kabushiki Kaisha Yakult Honsha (JP) | 2022-03-02 | — | — | EP | disclosed |
| US-20220008409-A1 | CANCER COMBINATION THERAPY USING QUINOLINE CARBOXAMIDE DERIVATIVE | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2022-01-13 | — | — | US | disclosed |
| EP-3854397-A1 | CANCER COMBINATION THERAPY USING QUINOLINE CARBOXAMIDE DERIVATIVE | Kabushiki Kaisha Yakult Honsha (JP) | 2021-07-28 | — | — | EP | disclosed |
| WO-2020218432-A1 | IMMUNE CHECKPOINT INHIBITOR COMBINATION THERAPY USING QUINOLINE CARBOXAMIDE DERIVATIVE | 株式会社ヤクルト本社 | 2020-10-29 | — | — | WO | disclosed |
| WO-2020059705-A1 | CANCER COMBINATION THERAPY USING QUINOLINE CARBOXAMIDE DERIVATIVE | 株式会社ヤクルト本社 | 2020-03-26 | — | — | WO | disclosed |
| EP-2325181-B1 | STAT3 INHIBITOR CONTAINING QUINOLINECARBOXAMIDE DERIVATIVE AS ACTIVE INGREDIENT | GENERAL INCORPORATED ASS PHARMA VALLEY PROJECT SUPPORTING ORGANIZATION (JP) | 2017-03-29 | — | — | EP | disclosed |
| US-8466290-B2 | STAT3 inhibitor containing quinolinecarboxamide derivative as active ingredient | PHARMA IP GENERAL INCORPORATED ASSOCIATION (JP) | 2013-06-18 | — | — | US | disclosed |
| US-20110172429-A1 | STAT3 INHIBITOR CONTAINING QUINOLINECARBOXAMIDE DERIVATIVE AS ACTIVE INGREDIENT | PHARMA IP GENERAL INCORPORATED ASSOCIATION (JP) | 2011-07-14 | — | — | US | disclosed |
| EP-2325181-A1 | STAT3 INHIBITOR CONTAINING QUINOLINECARBOXAMIDE DERIVATIVE AS ACTIVE INGREDIENT | Pharma Ip General Incorporated Association (JP) | 2011-05-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220008409-A1 | CANCER COMBINATION THERAPY USING QUINOLINE CARBOXAMIDE DERIVATIVE | JAK2, ROS1, ABL1 | STAT3 14/4885LMNA 4862/4885KDM4E 1390/4885 |
| US-20110172429-A1 | STAT3 INHIBITOR CONTAINING QUINOLINECARBOXAMIDE DERIVATIVE AS ACTIVE INGREDIENT | STAT3, STAT4, STAT5B | STAT3 1/4885LMNA 4766/4885KDM4E 532/4885 |
| US-20220218693-A1 | IMMUNE CHECKPOINT INHIBITOR COMBINATION THERAPY USING QUINOLINE CARBOXAMIDE DERIVATIVE | STAT3, PDCD1, CD274 | STAT3 1/4885LMNA 4467/4885KDM4E 460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.