Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.49 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.46 |
| ▸ | NOS2 | P35228 | 6/20 | 0.44 |
| ▸ | NOS3 | P29474 | 5/20 | 0.44 |
| ▸ | NOS1 | P29475 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | GSR | P00390 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ARG1 | P05089 | 3/20 | 0.39 |
| ▸ | ARG2 | P78540 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL453745 | 1.00 | OTC (0.49) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL6671444 | 1.00 | OTC (0.49) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL288809 | 1.00 | OTC (0.49) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL5698936 | 1.00 | OTC (0.49) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL1898346 | 1.00 | OTC (0.49) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL263652 | 1.00 | OTC (0.49) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL288808 | 1.00 | OTC (0.49) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL6946785 | 1.00 | OTC (0.49) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL20946267 | 1.00 | OTC (0.49) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL9537954 | 0.95 | OTC (0.46) | OTCDDAH1NOS2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 121 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9353357-B2 | Polypeptides having phytase activity and the encoding nucleic acids | AB ENZYMES GMBH (DE) | 2016-05-31 | — | — | US | claimed |
| WO-2015081088-A1 | DIRECT DETECTION OF RNA BY SURFACE INITIATED ENZYMATIC POLYMERIZATION | IMMUCOR, GTT DIAGNOSTICS, INC. (US) | 2015-06-04 | — | — | WO | claimed |
| US-20140242249-A1 | POLYPEPTIDE HAVING PHYTASE ACTIVITY AND INCREASED TEMPERATURE RESISTANCE OF THE ENZYME ACTIVITY, AND NUCLEOTIDE SEQUENCE CODING SAID POLYPEPTIDE | AB ENZYMES GMBH (DE) | 2014-08-28 | — | — | US | claimed |
| EP-2102334-B1 | POLYPEPTIDE HAVING PHYTASE ACTIVITY AND INCREASED TEMPERATURE RESISTANCE OF THE ENZYME ACTIVITY, AND NUCLEOTIDE SEQUENCE CODING SAID POLYPEPTIDE | AB ENZYMES GMBH (DE) | 2013-04-03 | — | — | EP | claimed |
| US-20110262619-A1 | POLYPEPTIDE HAVING PHYTASE ACTIVITY AND INCREASED TEMPERATURE RESISTANCE OF THE ENZYME ACTIVITY, AND NUCLEOTIDE SEQUENCE CODING SAID POLYPEPTIDE | AB ENZYMES GMBH (DE) | 2011-10-27 | — | — | US | claimed |
| CN-101631855-A | Polypeptide having phytase activity and increased temperature resistance of the enzyme activity, and nucleotide sequence coding said polypeptide | AB ENZYMES GMBH | 2010-01-20 | — | — | CN | claimed |
| EP-4381047-A1 | MODIFICATION OF CELLS WITH HETEROLOGOUS T-CELL RECEPTOR (TCR) CODING SEQUENCES | Adaptimmune Limited (GB) | 2024-06-12 | — | — | EP | disclosed |
| US-11969268-B2 | Systems and methods for home transdermal assessment of gastrointestinal function | MEDIBEACON INC. (US) | 2024-04-30 | — | — | US | disclosed |
| WO-2024085222-A1 | METHOD FOR DETECTING PROGRANULIN | 大塚製薬株式会社 | 2024-04-25 | — | — | WO | disclosed |
| WO-2024084667-A1 | METHOD FOR DETECTING PROGRANULIN | 大塚製薬株式会社 | 2024-04-25 | — | — | WO | disclosed |
| EP-3930760-B1 | CELL MEMBRANE PENETRATING CONJUGATES FOR GENE EDITING | CYGENICA LTD (IE) | 2024-01-10 | — | — | EP | disclosed |
| US-20230241234-A1 | CELL MEMBRANE PENETRATING CONJUGATES | CYGENICA LIMITED (IE) | 2023-08-03 | — | — | US | disclosed |
| WO-2023112992-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING DISEASES, DISORDERS, OR SYMPTOMS RELATED TO ABNORMALITY IN IMMUNE SYSTEM | レグセル株式会社 | 2023-06-22 | — | — | WO | disclosed |
| WO-1993013794-A1 | NOVEL METHODS AND COMPOSITIONS FOR TREATMENT OF ANGIOGENIC DISEASES | REPLIGEN CORPORATION (US) | 1993-07-22 | — | — | WO | disclosed |
| WO-1993008824-A1 | SYNTHETIC LUNG SURFACTANT HAVING ANTIOXIDANT PROPERTIES | MERRELL DOW PHARMACEUTICALS, INC. (US) | 1993-05-13 | — | — | WO | disclosed |
| EP-0397821-A4 | A NOVEL FAMILY OF HIGH AFFINITY, MODIFIED ANTIBODIES FOR CANCER TREATMENT | — | 1992-03-18 | — | — | EP | disclosed |
| EP-0397821-A1 | A NOVEL FAMILY OF HIGH AFFINITY, MODIFIED ANTIBODIES FOR CANCER TREATMENT | THE DOW CHEMICAL COMPANY (a Delaware corporation) (US) | 1990-11-22 | — | — | EP | disclosed |
| WO-1990004410-A1 | A NOVEL FAMILY OF HIGH AFFINITY, MODIFIED ANTIBODIES FOR CANCER TREATMENT | THE DOW CHEMICAL COMPANY (US) | 1990-05-03 | — | — | WO | disclosed |
| US-4797469-A | PANCREATIC GROWTH HORMONE RELEASING FACTOR | SANOFI (FR) | 1989-01-10 | — | — | US | disclosed |
| US-4704450-A | OLIGO- AND POLYPEPTIDES | SANOFI (FR) | 1987-11-03 | — | — | US | disclosed |