Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGA | O60502 | 19/20 | 1.00 |
| ▸ | HEXB | P07686 | 5/20 | 1.00 |
| ▸ | HEXA | P06865 | 1/20 | 0.61 |
| ▸ | HOGA1 | Q86XE5 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12676107 | 1.00 | OGA (1.00) | OGAHEXBHEXAHOGA1 | |
| SCHEMBL14240215 | 1.00 | OGA (1.00) | OGAHEXBHEXAHOGA1 | |
| SCHEMBL12676186 | 1.00 | OGA (1.00) | OGAHEXBHEXAHOGA1 | |
| SCHEMBL5020873 | 0.90 | OGA (0.82) | OGAHEXBHEXAHOGA1 | |
| SCHEMBL15364757 | 0.90 | OGA (0.82) | OGAHEXBHEXAHOGA1 | |
| SCHEMBL4538051 | 0.90 | OGA (0.82) | OGAHEXBHEXAHOGA1 | |
| SCHEMBL12611271 | 0.89 | OGA (1.00) | OGAHEXBHEXAHOGA1 | |
| SCHEMBL4537094 | 0.89 | OGA (0.81) | OGAHEXBHEXAHOGA1 | |
| SCHEMBL18524371 | 0.87 | OGA (0.78) | OGAHEXBHEXA | |
| SCHEMBL12611157 | 0.87 | OGA (0.78) | OGAHEXBHEXA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2322529-B1 | Selective glycosidase inhibitors and uses thereof | UNIV FRASER SIMON (CA) | 2017-12-06 | — | — | EP | claimed |
| US-8962664-B2 | Selective glycosidase inhibitors and uses thereof | SIMON FRASER UNIVERSITY (CA) | 2015-02-24 | — | — | US | claimed |
| EP-2322529-B1 | Selective glycosidase inhibitors and uses thereof | UNIV FRASER SIMON (CA) | 2017-12-06 | — | — | EP | disclosed |
| US-9469657-B2 | Glycosidase inhibitors | MERCK PATENT GMBH (DE) | 2016-10-18 | — | — | US | disclosed |
| US-9469657-B2 | Glycosidase inhibitors | MERCK PATENT GMBH (DE) | 2016-10-18 | — | — | US | disclosed |
| US-8962664-B2 | Selective glycosidase inhibitors and uses thereof | SIMON FRASER UNIVERSITY (CA) | 2015-02-24 | — | — | US | disclosed |
| US-8962664-B2 | Selective glycosidase inhibitors and uses thereof | SIMON FRASER UNIVERSITY (CA) | 2015-02-24 | — | — | US | disclosed |
| US-8884023-B2 | Pyrano [3,2-D][1,3]thiazole as glycosidase inhibitors | MERCK PATENT GMBH (DE) | 2014-11-11 | — | — | US | disclosed |
| US-8884023-B2 | Pyrano [3,2-D][1,3]thiazole as glycosidase inhibitors | MERCK PATENT GMBH (DE) | 2014-11-11 | — | — | US | disclosed |
| US-20140243370-A1 | Pyrano[3,2-D][1,3]thiazole as glycosidase inhibitors | MERCK PATENT GMBH (DE) | 2014-08-28 | — | — | US | disclosed |
| US-20140243370-A1 | Pyrano[3,2-D][1,3]thiazole as glycosidase inhibitors | MERCK PATENT GMBH (DE) | 2014-08-28 | — | — | US | disclosed |
| WO-2013028715-A1 | PYRANO [3, 2 - D] [1, 3] THIAZOLE AS GLYCOSIDASE INHIBITORS | MERCK PATENT GMBH (DE) | 2013-02-28 | — | — | WO | disclosed |
| US-8334310-B2 | Selective glycosidase inhibitors and uses thereof | SIMON FRASER UNIVERSITY (CA) | 2012-12-18 | — | — | US | disclosed |
| US-8334310-B2 | Selective glycosidase inhibitors and uses thereof | SIMON FRASER UNIVERSITY (CA) | 2012-12-18 | — | — | US | disclosed |
| US-20120316207-A1 | SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF | SIMON FRASER UNIVERSITY (CA) | 2012-12-13 | — | — | US | disclosed |
| US-20120316207-A1 | SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF | SIMON FRASER UNIVERSITY (CA) | 2012-12-13 | — | — | US | disclosed |
| EP-2322529-A1 | Selective glycosidase inhibitors and uses thereof | Simon Fraser University (CA) | 2011-05-18 | — | — | EP | disclosed |
| US-20100016386-A1 | SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF | SIMON FRASER UNIVERSITY (CA) | 2010-01-21 | — | — | US | disclosed |
| US-20100016386-A1 | SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF | SIMON FRASER UNIVERSITY (CA) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140243370-A1 | Pyrano[3,2-D][1,3]thiazole as glycosidase inhibitors | GBA3, GAA, BACE1 | OGA 251/4885HEXB 113/4885HEXA 85/4885 |
| US-20100016386-A1 | SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF | ENGASE, OGA, GALE | OGA 2/4885HEXB 37/4885HEXA 36/4885 |
| US-20120316207-A1 | SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF | ENGASE, OGA, GALE | OGA 2/4885HEXB 40/4885HEXA 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.