SCHEMBL189844

SCHEMBL189844

O=Cc1cc(Cl)cc(Cl)c1Cl

nearest known ligand 0.61

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 5/20 0.61
TDP1 Q9NUW8 1/20 0.54
ALDH1A1 P00352 6/20 0.52
PTPN1 P18031 1/20 0.43
TSHR P16473 4/20 0.42
HSD17B10 Q99714 3/20 0.42
AHR P35869 3/20 0.42
HPGD P15428 1/20 0.42
ORAI1 Q96D31 1/20 0.36
CYP3A4 P08684 2/20 0.36
RECQL P46063 1/20 0.36
MAPT P10636 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29818677 0.87 ERN1 (0.64) ERN1TDP1ALDH1A1PTPN1TSHR
SCHEMBL14877158 0.82 ERN1 (0.64) ERN1TDP1ALDH1A1PTPN1TSHR
SCHEMBL28029091 0.81 ERN1 (0.57) ERN1TDP1ALDH1A1PTPN1TSHR
SCHEMBL28337241 0.79 ERN1 (0.96) ERN1TDP1ALDH1A1TSHRHSD17B10
SCHEMBL1312079 0.77 CYP3A4 (0.50) ERN1TDP1ALDH1A1PTPN1TSHR
SCHEMBL2310769 0.76 ERN1 (0.57) ERN1TDP1ALDH1A1PTPN1TSHR
SCHEMBL15057515 0.76 ERN1 (0.64) ERN1TDP1ALDH1A1TSHRHSD17B10
SCHEMBL664931 0.76 ERN1 (0.47) ERN1TDP1ALDH1A1PTPN1CYP3A4
SCHEMBL29382880 0.76 ERN1 (1.00) ERN1TDP1ALDH1A1TSHRHSD17B10
SCHEMBL17512175 0.76 ERN1 (0.57) ERN1TDP1ALDH1A1PTPN1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 285 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118459420-A Thiazolinone compound containing multiple halogen atoms and preparation method thereof 南京工业大学 2024-08-09 CN claimed
CN-118459422-A Thiazole thiazolinone compound containing multiple halogen atoms and preparation method thereof 南京工业大学 2024-08-09 CN claimed
WO-2016029146-A1 SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE UNIVERSITY OF WASHINGTON (US) 2016-02-25 WO claimed
US-9234087-B2 Preparation for initiating radical reactions UNITED INITIATORS GMBH & CO. KG (DE) 2016-01-12 US claimed
EP-2288652-B1 PREPARATION FOR INITIATING RADICAL REACTIONS UNITED INITIATORS GMBH & CO KG (DE) 2012-09-19 EP claimed
EP-2130858-B1 Preparations to initiate radical reactions UNITED INITIATORS GMBH & CO KG (DE) 2012-07-25 EP claimed
US-20110272628-A1 Preparation For Initiating Radical Reactions UNITED INITIATORS GMBH (DE) 2011-11-10 US claimed
EP-2288652-A1 PREPARATION FOR INITIATING RADICAL REACTIONS United Initiators GmbH & Co. KG (DE) 2011-03-02 EP claimed
WO-2009146916-A1 PREPARATION FOR INITIATING RADICAL REACTIONS UNITED INITIATORS GMBH & CO. KG (DE) 2009-12-10 WO claimed
EP-2130858-A1 Preparations to initiate radical reactions Degussa Initiators GmbH & Co. KG (DE) 2009-12-09 EP claimed
EP-1390336-A1 METHOD FOR PRODUCING AROMATIC ALDEHYDES AND KETONES BY THE CATALYTIC OXIDATION OF ALKYL-AROMATIC COMPOUNDS DSM Fine Chemicals Austria Nfg GmbH & Co KG (AT) 2004-02-25 EP claimed
EP-1381359-A1 AURONES AS TELOMERASE INHIBITORS Pharmacia Italia S.p.A. (IT) 2004-01-21 EP claimed
JP-2003532702-A 2003-11-05 JP claimed
US-20030149053-A1 Process for the preparation of pyrazine compounds Jazz Pharmaceuticals, Inc. 2003-08-07 US claimed
EP-1278721-A1 PROCESS FOR THE PREPARATION OF PYRAZINE COMPOUNDS GLAXO GROUP LIMITED (GB) 2003-01-29 EP claimed
WO-2002096849-A1 METHOD FOR PRODUCING AROMATIC ALDEHYDES AND KETONES BY THE CATALYTIC OXIDATION OF ALKYL-AROMATIC COMPOUNDS DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG (AT) 2002-12-05 WO claimed
WO-2002083123-A1 AURONES AS TELOMERASE INHIBITORS PHARMACIA ITALIA SPA (IT) 2002-10-24 WO claimed
WO-2001085674-A1 PROCESS FOR THE PREPARATION OF PYRAZINE COMPOUNDS GLAXO GROUP LIMITED (GB) 2001-11-15 WO claimed
US-4868241-A POLYVINYL ALCOHOL MODIFIED WITH BENZOIC ACID DERIVATIVE AMERICAN CYANAMID COMPANY (US) 1989-09-19 US claimed
EP-0231922-A2 Electron beam and X-ray resists AMERICAN CYANAMID COMPANY (US) 1987-08-12 EP claimed