Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | SCD | O00767 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.39 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16676649 | 0.83 | POLB (0.45) | BRD4SCDPOLBTDP1PLK1 | |
| SCHEMBL28051960 | 0.82 | MKNK1 (0.50) | BRD4SCDIDO1PARP1GRM5 | |
| SCHEMBL16505468 | 0.78 | BRD4 (0.72) | BRD4IDO1GRM5KDM4EALDH1A1 | |
| SCHEMBL15966073 | 0.78 | PARP1 (0.52) | BRD4PLK1PARP1KDM4EALDH1A1 | |
| SCHEMBL29289961 | 0.77 | PARP1 (0.49) | BRD4PLK1PARP1GRM5KDM4E | |
| SCHEMBL27481112 | 0.76 | BRD4 (0.50) | BRD4SCDIDO1GRM5KDM4E | |
| SCHEMBL7218347 | 0.75 | PARP1 (0.50) | BRD4SCDPOLBTDP1PLK1 | |
| SCHEMBL30695551 | 0.74 | PLK1 (0.46) | PLK1PARP1GRM5KDM4EALDH1A1 | |
| SCHEMBL3724024 | 0.74 | EGLN2 (0.60) | PLK1PARP1KDM4EALDH1A1EGLN2 | |
| SCHEMBL8568914 | 0.74 | PLK1 (0.46) | PLK1PARP1GRM5KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3390361-A1 | N-PHENYL-PYRIDINE-2-CARBOXAMIDE DERIVATIVES AND THEIR USE AS PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION MODULATORS | Incyte Corporation (US) | 2018-10-24 | — | — | EP | claimed |
| WO-2017106634-A1 | N-PHENYL-PYRIDINE-2-CARBOXAMIDE DERIVATIVES AND THEIR USE AS PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION MODULATORS | INCYTE CORPORATION (US) | 2017-06-22 | — | — | WO | claimed |