Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 1.00 |
| ▸ | TEC | P42680 | 10/20 | 0.76 |
| ▸ | TXK | P42681 | 10/20 | 0.76 |
| ▸ | BMX | P51813 | 10/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18996809 | 0.94 | BTK (1.00) | BTKTECTXKBMX | |
| SCHEMBL18996807 | 0.91 | BTK (1.00) | BTKTECTXKBMX | |
| SCHEMBL18996811 | 0.90 | BTK (1.00) | BTKTECTXKBMX | |
| SCHEMBL18996800 | 0.89 | BTK (1.00) | BTKTECTXKBMX | |
| SCHEMBL19001909 | 0.88 | BTK (0.79) | BTKTECTXKBMX | |
| SCHEMBL18996812 | 0.87 | BTK (1.00) | BTKTECTXKBMX | |
| SCHEMBL18996808 | 0.86 | BTK (1.00) | BTKTECTXKBMX | |
| SCHEMBL18996804 | 0.85 | BTK (1.00) | BTKTECTXKBMX | |
| SCHEMBL18996792 | 0.84 | BTK (1.00) | BTKTECTXKBMX | |
| SCHEMBL18996763 | 0.83 | BTK (1.00) | BTKTECTXKBMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210009567-A1 | HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2021-01-14 | — | — | US | disclosed |
| US-20200055843-A1 | HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2020-02-20 | — | — | US | disclosed |
| US-20190092759-A1 | HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2019-03-28 | — | — | US | disclosed |
| US-20180222893-A1 | HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2018-08-09 | — | — | US | disclosed |
| US-20180222893-A1 | HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2018-08-09 | — | — | US | disclosed |
| US-9975882-B2 | Heteroaromatic compounds as BTK inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-05-22 | — | — | US | disclosed |
| US-9975882-B2 | Heteroaromatic compounds as BTK inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-05-22 | — | — | US | disclosed |
| US-20180030037-A1 | HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2018-02-01 | — | — | US | disclosed |
| US-20180030037-A1 | HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2018-02-01 | — | — | US | disclosed |
| US-9815822-B2 | — | — | 2017-11-14 | — | — | US | disclosed |
| US-9815822-B2 | — | — | 2017-11-14 | — | — | US | disclosed |
| US-20170174663-A1 | HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-06-22 | — | — | US | disclosed |
| US-20170174663-A1 | HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180222893-A1 | HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS | BTK, SYK, LCK | BTK 1/4885TEC 7/4885TXK 263/4885 |
| US-20200055843-A1 | HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS | BTK, SYK, LCK | BTK 1/4885TEC 7/4885TXK 263/4885 |
| US-20170174663-A1 | HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS | BTK, SYK, LCK | BTK 1/4885TEC 7/4885TXK 263/4885 |
| US-20180030037-A1 | HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS | BTK, SYK, LCK | BTK 1/4885TEC 7/4885TXK 263/4885 |
| US-20190092759-A1 | HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS | BTK, SYK, LCK | BTK 1/4885TEC 7/4885TXK 263/4885 |
| US-20210009567-A1 | HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS | BTK, SYK, LCK | BTK 1/4885TEC 7/4885TXK 263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.