Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.63 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23099877 | 0.96 | SLC6A2 (0.63) | SLC6A2SLC6A4SLC6A3KMT2AMEN1 | |
| SCHEMBL7235082 | 0.92 | SLC6A2 (0.67) | SLC6A2SLC6A4SLC6A3KMT2AMEN1 | |
| Formic Acid SCHEMBL28317621 | 0.90 | SLC6A2 (0.54) | SLC6A2SLC6A4SLC6A3KMT2AMEN1 | |
| SCHEMBL15039647 | 0.84 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3KMT2AMEN1 | |
| SCHEMBL254980 | 0.84 | HRH1 (0.62) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL16569940 | 0.84 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3KMT2AMEN1 | |
| SCHEMBL2298024 | 0.84 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3KMT2AMEN1 | |
| SCHEMBL18186076 | 0.84 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL29981033 | 0.82 | HRH1 (0.61) | SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL3472570 | 0.82 | HRH1 (0.61) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9993477-B2 | Substituted imidazo[1,5-a]pyrazines as PDE9 inhibitors | H. LUNDBECK A/S (DK) | 2018-06-12 | — | — | US | disclosed |
| US-20170173018-A1 | SUBSTITUTED IMIDAZO[1,5-a]PYRAZINES AS PDE9 INHIBITORS | SUNDIA MEDITECH COMPANY, LTD. (CN) | 2017-06-22 | — | — | US | disclosed |
| US-20140088081-A1 | Amino-Heterocyclic Compounds | PFIZER INC. (US) | 2014-03-27 | — | — | US | disclosed |
| US-20120329777-A1 | Amino-Heterocyclic Compounds | PFIZER INC. | 2012-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120329777-A1 | Amino-Heterocyclic Compounds | PDE9A, PDE2A, PDE10A | SLC6A2 411/4885SLC6A4 640/4885SLC6A3 122/4885 |
| US-20170173018-A1 | SUBSTITUTED IMIDAZO[1,5-a]PYRAZINES AS PDE9 INHIBITORS | PDE9A, PDE12, PDE5A | SLC6A2 766/4885SLC6A4 1190/4885SLC6A3 549/4885 |
| US-20140088081-A1 | Amino-Heterocyclic Compounds | PDE9A, PDE2A, PDE10A | SLC6A2 411/4885SLC6A4 640/4885SLC6A3 122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.