Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19001116 | 1.00 | CNR2 (0.49) | CNR2HCRTR1HCRTR2GRIN2BMAPT | |
| SCHEMBL26796035 | 0.93 | CNR2 (0.42) | CNR2HCRTR1HCRTR2GRIN2BMAPT | |
| SCHEMBL26151690 | 0.85 | HCRTR1 (0.43) | CNR2HCRTR1HCRTR2GRIN2BMAPT | |
| SCHEMBL14349205 | 0.84 | MAPT (0.46) | MAPTHRH3TRPV1KDM4EABL1 | |
| SCHEMBL21081457 | 0.84 | HDAC1 (0.45) | CNR2HCRTR1HCRTR2GRIN2BMAPT | |
| SCHEMBL19001098 | 0.83 | KMT2A (0.49) | HCRTR1HCRTR2GRIN2BMAPTHSD11B1 | |
| SCHEMBL13658045 | 0.83 | KMT2A (0.49) | HCRTR1HCRTR2GRIN2BMAPTHSD11B1 | |
| SCHEMBL14349536 | 0.83 | KMT2A (0.49) | HCRTR1HCRTR2GRIN2BMAPTHSD11B1 | |
| SCHEMBL12139652 | 0.83 | KMT2A (0.49) | HCRTR1HCRTR2GRIN2BMAPTHSD11B1 | |
| SCHEMBL26151680 | 0.83 | HCRTR1 (0.39) | CNR2HCRTR1HCRTR2GRIN2BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9938292-B2 | Quinoline derivatives as SMO inhibitors | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2018-04-10 | — | — | US | disclosed |
| US-20170174703-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170174703-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | SMO, GLI1, SHH | CNR2 879/4885HCRTR1 1833/4885HCRTR2 1913/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.