Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 16/20 | 0.66 |
| ▸ | SCN5A | Q14524 | 7/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.66 |
| ▸ | SCN1A | P35498 | 2/20 | 0.49 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22089147 | 0.97 | SCN9A (0.67) | SCN9ASCN5ACYP3A4SCN1ASCN8A | |
| SCHEMBL18992436 | 0.95 | SCN9A (0.62) | SCN9ASCN5ACYP3A4SCN1ASCN8A | |
| SCHEMBL18992638 | 0.94 | SCN9A (0.64) | SCN9ASCN5ACYP3A4SCN1ASCN8A | |
| SCHEMBL19001188 | 0.92 | SCN9A (0.63) | SCN9ASCN5ACYP3A4SCN1ASCN8A | |
| SCHEMBL19001194 | 0.91 | SCN9A (0.62) | SCN9ASCN5ACYP3A4SCN1ASCN8A | |
| SCHEMBL18992319 | 0.90 | SCN9A (0.59) | SCN9ASCN5ACYP3A4SCN1ASCN8A | |
| SCHEMBL20586569 | 0.89 | SCN9A (0.58) | SCN9ASCN5ACYP3A4SCN1ASCN8A | |
| SCHEMBL30518279 | 0.89 | SCN9A (0.58) | SCN9ASCN5ACYP3A4SCN1ASCN8A | |
| SCHEMBL18992201 | 0.89 | SCN9A (0.58) | SCN9ASCN5ACYP3A4SCN1ASCN8A | |
| SCHEMBL19000935 | 0.89 | SCN9A (0.58) | SCN9ASCN5ACYP3A4SCN1ASCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3389654-B1 | DIAMINO-ALKYLAMINO-LINKED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | MERCK SHARP & DOHME LLC (US) | 2023-08-16 | — | — | EP | disclosed |
| EP-3390374-B1 | HYDROXYALKYLAMINE- AND HYDROXYCYCLOALKYLAMINE-SUBSTITUTED DIAMINE-ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | MERCK SHARP & DOHME (US) | 2020-08-26 | — | — | EP | disclosed |
| WO-2017106409-A1 | DIAMINO-ALKYLAMINO-LINKED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | MERCK SHARP & DOHME CORP. (US) | 2017-06-22 | — | — | WO | disclosed |
| WO-2017106226-A1 | HYDROXYALKYLAMINE- AND HYDROXYCYCLOALKYLAMINE-SUBSTITUTED DIAMINE-ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | MERCK SHARP & DOHME CORP. (US) | 2017-06-22 | — | — | WO | disclosed |