Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 12/20 | 0.94 |
| ▸ | SCN1A | P35498 | 1/20 | 0.94 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.79 |
| ▸ | SCN5A | Q14524 | 10/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18992625 | 0.99 | SCN9A (0.95) | SCN9ASCN1ACYP3A4SCN5A | |
| SCHEMBL18992589 | 0.99 | SCN9A (0.95) | SCN9ASCN1ACYP3A4SCN5A | |
| SCHEMBL20586567 | 0.99 | SCN9A (0.95) | SCN9ASCN1ACYP3A4SCN5A | |
| SCHEMBL20167681 | 0.98 | SCN9A (0.94) | SCN9ASCN1ACYP3A4SCN5A | |
| SCHEMBL30626708 | 0.98 | SCN9A (0.94) | SCN9ASCN1ACYP3A4SCN5A | |
| SCHEMBL18992227 | 0.97 | SCN9A (1.00) | SCN9ASCN1ACYP3A4SCN5A | |
| SCHEMBL18992917 | 0.97 | SCN9A (1.00) | SCN9ASCN1ACYP3A4SCN5A | |
| SCHEMBL18992225 | 0.97 | SCN9A (1.00) | SCN9ASCN1ACYP3A4SCN5A | |
| SCHEMBL18992770 | 0.93 | SCN9A (0.89) | SCN9ASCN1ACYP3A4SCN5A | |
| SCHEMBL18992390 | 0.93 | SCN9A (0.89) | SCN9ASCN1ACYP3A4SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017106409-A1 | DIAMINO-ALKYLAMINO-LINKED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | MERCK SHARP & DOHME CORP. (US) | 2017-06-22 | — | — | WO | disclosed |