Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 3/20 | 0.77 |
| ▸ | GAA | P10253 | 4/20 | 0.72 |
| ▸ | TSHR | P16473 | 1/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | PARP1 | P09874 | 4/20 | 0.59 |
| ▸ | HTR1A | P08908 | 3/20 | 0.58 |
| ▸ | HTR7 | P34969 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3394834 | 0.88 | DRD4 (0.84) | DRD4GAATSHRHSD17B10ALDH1A1 | |
| SCHEMBL13281133 | 0.87 | DRD4 (1.00) | DRD4GAATSHRHSD17B10ALDH1A1 | |
| SCHEMBL3400090 | 0.83 | DRD4 (0.77) | DRD4GAATSHRHSD17B10ALDH1A1 | |
| SCHEMBL29111343 | 0.83 | GAA (0.61) | DRD4GAATSHRHSD17B10ALDH1A1 | |
| SCHEMBL14585685 | 0.82 | GAA (0.78) | DRD4GAATSHRHSD17B10ALDH1A1 | |
| SCHEMBL3394699 | 0.82 | GAA (0.74) | DRD4GAATSHRHSD17B10ALDH1A1 | |
| SCHEMBL3399978 | 0.80 | DRD4 (1.00) | DRD4GAATSHRHSD17B10ALDH1A1 | |
| SCHEMBL3400261 | 0.80 | DRD4 (0.77) | DRD4GAATSHRHSD17B10ALDH1A1 | |
| SCHEMBL22639886 | 0.79 | GAA (0.73) | DRD4GAATSHRHSD17B10ALDH1A1 | |
| SCHEMBL3397598 | 0.78 | DRD4 (0.78) | DRD4GAATSHRHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10668076-B1 | Compositions and methods of targeting mutant K-Ras | NANTBIO, INC. (US) | 2020-06-02 | — | — | US | disclosed |
| US-9687491-B1 | Compositions and methods of targeting mutant K-Ras | NANTBIOSCIENCE, INC. (US) | 2017-06-27 | — | — | US | disclosed |
| US-9687491-B1 | Compositions and methods of targeting mutant K-Ras | NANTBIOSCIENCE, INC. (US) | 2017-06-27 | — | — | US | disclosed |
| US-9687491-B1 | Compositions and methods of targeting mutant K-Ras | NANTBIOSCIENCE, INC. (US) | 2017-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10668076-B1 | Compositions and methods of targeting mutant K-Ras | KRAS, NRAS, HRAS | DRD4 4580/4885GAA 2670/4885TSHR 3932/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.