Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25220860 | 0.82 | KDM4E (0.46) | KDM4EALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL6039162 | 0.80 | KDM1A (0.48) | KDM4EALDH1A1EGFRHSD17B10 | |
| SCHEMBL9776713 | 0.80 | MAPT (0.58) | KDM4EALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL15858031 | 0.79 | KDM4E (0.43) | KDM4EALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL8888867 | 0.79 | USP2 (0.52) | KDM4EALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL25239934 | 0.79 | MEN1 (0.48) | KDM4EALDH1A1MAPTKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL8892373 | 0.78 | EGFR (0.49) | KDM4EALDH1A1EGFRTNKSTNKS2 | |
| SCHEMBL30013215 | 0.78 | KDM4E (0.51) | KDM4EALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL1353177 | 0.78 | KDM4E (0.51) | KDM4EALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL15857861 | 0.78 | KDM4E (0.42) | KDM4EALDH1A1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2938344-B1 | PIPERAZINE-SUBSTITUTED [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES | MERCK SHARP & DOHME (US) | 2017-06-21 | — | — | EP | disclosed |