Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 19/20 | 0.77 |
| ▸ | TNKS | O95271 | 1/20 | 0.67 |
| ▸ | PARP6 | Q2NL67 | 1/20 | 0.67 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.67 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.67 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.67 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.67 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.67 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.67 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.67 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.67 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.67 |
| ▸ | PRAP1 | Q96NZ9 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19005811 | 0.90 | PARP1 (0.76) | PARP1TNKSPARP6PARP15PARP14 | |
| SCHEMBL19005254 | 0.87 | PARP1 (0.80) | PARP1TNKSPARP6PARP15PARP14 | |
| SCHEMBL19005691 | 0.86 | PARP1 (0.79) | PARP1TNKSPARP6PARP15PARP14 | |
| SCHEMBL30888478 | 0.86 | PARP1 (0.79) | PARP1TNKSPARP6PARP15PARP14 | |
| SCHEMBL19005693 | 0.86 | PARP1 (0.79) | PARP1TNKSPARP6PARP15PARP14 | |
| SCHEMBL19005257 | 0.85 | PARP1 (0.78) | PARP1TNKSPARP6PARP15PARP14 | |
| SCHEMBL26121871 | 0.85 | PARP1 (0.62) | PARP1TNKSPARP6PARP15PARP14 | |
| SCHEMBL30546323 | 0.85 | PARP1 (0.62) | PARP1TNKSPARP6PARP15PARP14 | |
| SCHEMBL10025634 | 0.84 | PARP1 (0.77) | PARP1TNKSPARP6PARP15PARP14 | |
| SCHEMBL30888475 | 0.84 | PARP1 (1.00) | PARP1TNKSTNKS2PARP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017101796-A1 | PHTHALAZINONE DERIVATIVE, AND PREPARATION METHOD AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2017-06-22 | — | — | WO | disclosed |