Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | SLC34A1 | Q06495 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24506914 | 0.90 | SLC34A1 (0.46) | ESR2NR1H2DRD2MAPTSLC34A1 | |
| SCHEMBL24507073 | 0.85 | SLC34A1 (0.43) | ESR2NR1H2MAPTSLC34A1BACE1 | |
| SCHEMBL24507072 | 0.84 | SLC34A1 (0.42) | ESR2NR1H2MAPTSLC34A1BACE1 | |
| SCHEMBL21041598 | 0.80 | ESR2 (0.46) | ESR2NR1H2MAPT | |
| SCHEMBL16217169 | 0.79 | ESR2 (0.52) | ESR2NR1H2MAPTSLC34A1SMN1; SMN2 | |
| SCHEMBL16220598 | 0.78 | ESR2 (0.51) | ESR2NR1H2MAPTSLC34A1SMN1; SMN2 | |
| SCHEMBL17327921 | 0.78 | ESR2 (0.51) | ESR2NR1H2MAPTSLC34A1SMN1; SMN2 | |
| SCHEMBL17202601 | 0.78 | SLC34A1 (0.40) | ESR2NR1H2MAPTSLC34A1BACE1 | |
| SCHEMBL25447317 | 0.77 | ESR2 (0.46) | ESR2NR1H2MAPTSLC34A1PRMT5 | |
| SCHEMBL20764975 | 0.76 | ESR2 (0.44) | ESR2NR1H2MAPTSLC34A1PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107207504-B | Phthalazinone derivatives, preparation method and use thereof | 四川科伦博泰生物医药股份有限公司 | 2020-03-10 | — | — | CN | disclosed |
| WO-2017101796-A1 | PHTHALAZINONE DERIVATIVE, AND PREPARATION METHOD AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2017-06-22 | — | — | WO | disclosed |