Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | F12 | P00748 | 2/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | RBP4 | P02753 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21237549 | 0.92 | ADORA1 (0.45) | ADORA1ESR2NR1H2PARP1TNKS2 | |
| SCHEMBL17868704 | 0.90 | ESR2 (0.41) | ADORA1ESR2NR1H2PARP1TNKS2 | |
| SCHEMBL1424003 | 0.89 | DPP4 (0.46) | ADORA1ESR2NR1H2PARP1TNKS2 | |
| SCHEMBL17229883 | 0.84 | ADORA1 (0.45) | ADORA1ESR2NR1H2PARP1TNKS2 | |
| SCHEMBL17317597 | 0.83 | ADORA1 (0.44) | ADORA1ESR2NR1H2PARP1TNKS2 | |
| SCHEMBL17317969 | 0.83 | ADORA1 (0.50) | ADORA1ESR2NR1H2PARP1TNKS2 | |
| SCHEMBL19643783 | 0.83 | ADORA1 (0.44) | ADORA1ESR2NR1H2PARP1TNKS2 | |
| SCHEMBL17223055 | 0.82 | ADORA1 (0.49) | ADORA1ESR2NR1H2PARP1TNKS2 | |
| SCHEMBL10296218 | 0.82 | ESR2 (0.43) | ADORA1ESR2NR1H2PARP1TNKS2 | |
| SCHEMBL21994486 | 0.81 | ADORA1 (0.43) | ADORA1ESR2NR1H2PARP1TNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107207504-B | Phthalazinone derivatives, preparation method and use thereof | 四川科伦博泰生物医药股份有限公司 | 2020-03-10 | — | — | CN | disclosed |
| WO-2017101796-A1 | PHTHALAZINONE DERIVATIVE, AND PREPARATION METHOD AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2017-06-22 | — | — | WO | disclosed |