Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 17/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19006145 | 0.93 | PIK3CD (0.56) | PIK3CDPIK3CAPIK3CBPIK3CGKDM4E | |
| SCHEMBL19006158 | 0.93 | PIK3CD (0.56) | PIK3CDPIK3CAPIK3CBPIK3CGKDM4E | |
| SCHEMBL19006157 | 0.93 | PIK3CD (0.56) | PIK3CDPIK3CAPIK3CBPIK3CGKDM4E | |
| SCHEMBL19006298 | 0.93 | PIK3CD (0.54) | PIK3CDPIK3CAPIK3CBPIK3CGKDM4E | |
| SCHEMBL19006152 | 0.89 | PIK3CD (0.52) | PIK3CDPIK3CAPIK3CBPIK3CGKDM4E | |
| SCHEMBL18988837 | 0.89 | PIK3CD (0.52) | PIK3CDPIK3CAPIK3CBPIK3CGKDM4E | |
| SCHEMBL18988838 | 0.89 | PIK3CD (0.52) | PIK3CDPIK3CAPIK3CBPIK3CGKDM4E | |
| SCHEMBL19006150 | 0.88 | PIK3CD (0.60) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL19006148 | 0.87 | PIK3CD (0.50) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL19006153 | 0.87 | PIK3CD (0.50) | PIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017103825-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | LUPIN LIMITED (IN) | 2017-06-22 | — | — | WO | disclosed |