Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19006914 | 0.92 | MAPK1 (0.53) | MAPK1KMT2AMEN1CSF1RPDE4A | |
| SCHEMBL15869890 | 0.82 | MAPK1 (0.50) | MAPK1KMT2AMEN1PDE4AADORA2A | |
| SCHEMBL14907967 | 0.78 | PDE4A (0.55) | MAPK1KMT2AMEN1PDE4AADORA2A | |
| SCHEMBL19006847 | 0.77 | PDE1A (0.60) | MAPK1KMT2AMEN1ADORA2BLMNA | |
| SCHEMBL15869891 | 0.73 | PDE1A (0.54) | MAPK1KMT2AMEN1ADORA2BLMNA | |
| SCHEMBL15869889 | 0.73 | HIF1A (0.56) | MAPK1KMT2AMEN1ADORA2BLMNA | |
| SCHEMBL14907925 | 0.70 | MAPK1 (0.55) | MAPK1KMT2AMEN1PDE4AADORA2A | |
| SCHEMBL23974590 | 0.70 | ADORA2A (0.63) | MAPK1PDE4AADORA2APDE4BPDE4C | |
| SCHEMBL10394509 | 0.70 | MAPK1 (0.73) | MAPK1KMT2AMEN1ADORA2BBLM | |
| SCHEMBL6662150 | 0.70 | KMT2A (0.45) | MAPK1KMT2AMEN1CSF1RPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2753333-B1 | CAFFEINATED COMPOUNDS AND COMPOSITIONS FOR TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES | PROTAMED INC (US) | 2017-06-21 | — | — | EP | disclosed |