Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.66 |
| ▸ | GAA | P10253 | 7/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 7/20 | 0.66 |
| ▸ | ALOX12 | P18054 | 7/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.66 |
| ▸ | MEN1 | O00255 | 4/20 | 0.66 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 6/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17021326 | 0.93 | MAPT (0.64) | MAPTALDH1A1KDM4EGAAALOX15 | |
| SCHEMBL17021287 | 0.93 | GAA (0.64) | MAPTALDH1A1KDM4EGAAALOX15 | |
| SCHEMBL19010256 | 0.90 | MAPT (0.51) | MAPTALDH1A1KDM4EGAAALOX15 | |
| SCHEMBL19010243 | 0.85 | MAPT (0.64) | MAPTALDH1A1KDM4EGAAALOX15 | |
| SCHEMBL2694834 | 0.83 | KDM4E (0.65) | MAPTALDH1A1KDM4EGAAALOX15 | |
| SCHEMBL19010332 | 0.83 | GFER (0.49) | MAPTALDH1A1KDM4EGAAALOX15 | |
| SCHEMBL19010258 | 0.83 | GFER (0.50) | MAPTALDH1A1KDM4EGAAALOX15 | |
| SCHEMBL19010274 | 0.82 | GFER (0.49) | MAPTALDH1A1KDM4EGAAALOX15 | |
| SCHEMBL19010322 | 0.82 | MAPT (0.59) | MAPTALDH1A1KDM4EGAAALOX15 | |
| SCHEMBL19010324 | 0.82 | MAPT (0.47) | MAPTALDH1A1KDM4EGAAALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834548-B2 | Pyridazine compounds as JAK inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2017-12-05 | — | — | US | disclosed |
| US-20170174673-A1 | PYRIDAZINE COMPOUNDS AS JAK INHIBITORS | ALEXION PHARMACEUTICALS, INC. | 2017-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170174673-A1 | PYRIDAZINE COMPOUNDS AS JAK INHIBITORS | JAK1, JAK2, JAK3 | MAPT 53/4885ALDH1A1 2112/4885KDM4E 1321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.