Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 10/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19011554 | 0.85 | KMT2A (0.38) | HCRTR2HCRTR1PRKCQ | |
| SCHEMBL12524335 | 0.80 | NOTUM (0.45) | NOTUMKEAP1HCRTR2HCRTR1PRKCQ | |
| SCHEMBL10187666 | 0.79 | CHRNA7 (0.36) | NOTUMHCRTR2HCRTR1USP30SLC6A2 | |
| SCHEMBL12166225 | 0.79 | NOTUM (0.38) | NOTUMKEAP1HCRTR2HCRTR1PRKCQ | |
| SCHEMBL15362509 | 0.78 | NOTUM (0.38) | NOTUMKEAP1HCRTR2HCRTR1PRKCQ | |
| SCHEMBL19011534 | 0.75 | NOTUM (0.46) | NOTUM | |
| SCHEMBL12099625 | 0.75 | NOTUM (0.51) | NOTUMKEAP1HCRTR2HCRTR1MAPK8 | |
| SCHEMBL12099603 | 0.74 | NOTUM (0.46) | NOTUMKEAP1HCRTR2HCRTR1PRKCQ | |
| SCHEMBL19011581 | 0.73 | NOTUM (0.55) | NOTUMUSP30SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL12166207 | 0.72 | NOTUM (0.40) | NOTUMKEAP1HCRTR2HCRTR1PRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632255-B1 | DIAZENIUMDIOLATE HETEROCYCLIC DERIVATIVES | MERCK SHARP & DOHME (US) | 2017-06-21 | — | — | EP | disclosed |