SCHEMBL19014822

SCHEMBL19014822

CCOP(=O)(CN1CCN(CC[C@H](CSc2ccccc2)Nc2ccc(SNC(=O)c3ccc(N4CCN(Cc5ccccc5-c5ccc(Cl)cc5)CC4)cc3)cc2S(=O)(=O)C(F)(F)F)CC1)OCOC(=O)OC(C)C

nearest known ligand 0.62

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ BCL2L1 Q07817 20/20 0.62
▸ BCL2 P10415 15/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19014882 0.92 BCL2L1 (0.74) BCL2L1BCL2
SCHEMBL22409475 0.92 BCL2L1 (0.74) BCL2L1BCL2
SCHEMBL19014814 0.89 BCL2L1 (0.65) BCL2L1BCL2
SCHEMBL19014809 0.86 BCL2L1 (0.71) BCL2L1BCL2
SCHEMBL22409419 0.86 BCL2L1 (0.76) BCL2L1BCL2
SCHEMBL19014881 0.86 BCL2L1 (0.76) BCL2L1BCL2
SCHEMBL19014921 0.86 BCL2L1 (0.83) BCL2L1BCL2
SCHEMBL22409472 0.82 BCL2L1 (0.77) BCL2L1BCL2
SCHEMBL19014790 0.82 BCL2L1 (0.77) BCL2L1BCL2
SCHEMBL19014821 0.82 BCL2L1 (0.82) BCL2L1BCL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017101851-A1 ACYLSULFONAMIDE DERIVATIVES FOR TREATING SENESCENCE-ASSOCIATED DISEASES AND DISORDERS UNITY BIOTECHNOLOGY, INC. (US) 2017-06-22 — — WO disclosed
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