Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CCND3 | P30281 | 1/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 7/20 | 0.34 |
| ▸ | MET | P08581 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15741987 | 1.00 | CDK4 (0.39) | CDK4CCND1CCND3CDK6KDM4C | |
| SCHEMBL15749050 | 1.00 | CDK4 (0.39) | CDK4CCND1CCND3CDK6KDM4C | |
| SCHEMBL15743089 | 0.91 | KDM4C (0.42) | CDK4CCND1CCND3CDK6KDM4C | |
| SCHEMBL15743088 | 0.91 | KDM4C (0.42) | CDK4CCND1CCND3CDK6KDM4C | |
| SCHEMBL15749054 | 0.83 | EGFR (0.37) | KDM4CL3MBTL1P2RX3EGFR | |
| SCHEMBL15742165 | 0.83 | EGFR (0.37) | KDM4CL3MBTL1P2RX3EGFR | |
| SCHEMBL15749857 | 0.83 | EGFR (0.37) | KDM4CL3MBTL1P2RX3EGFR | |
| SCHEMBL19015609 | 0.83 | EGFR (0.37) | KDM4CL3MBTL1P2RX3EGFR | |
| SCHEMBL15742167 | 0.83 | EGFR (0.37) | KDM4CL3MBTL1P2RX3EGFR | |
| SCHEMBL17103728 | 0.83 | EGFR (0.37) | KDM4CL3MBTL1P2RX3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3181564-B1 | AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS | HOFFMANN LA ROCHE (CH) | 2019-09-18 | — | — | EP | disclosed |
| EP-3181564-B1 | AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS | HOFFMANN LA ROCHE (CH) | 2019-09-18 | — | — | EP | disclosed |
| EP-2922851-B1 | AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS | GENENTECH INC (US) | 2017-07-26 | — | — | EP | disclosed |
| EP-3181564-A1 | AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS | Genentech, Inc. (US) | 2017-06-21 | — | — | EP | disclosed |