Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | OGA | O60502 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | DKK1 | O94907 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15740505 | 1.00 | EGFR (0.50) | EGFRKDM1APDE4DDYRK1AHRH3 | |
| SCHEMBL29958987 | 1.00 | EGFR (0.50) | EGFRKDM1APDE4DDYRK1AHRH3 | |
| SCHEMBL15740731 | 1.00 | EGFR (0.50) | EGFRKDM1APDE4DDYRK1AHRH3 | |
| SCHEMBL29958815 | 1.00 | EGFR (0.50) | EGFRKDM1APDE4DDYRK1AHRH3 | |
| SCHEMBL30733190 | 1.00 | EGFR (0.50) | EGFRKDM1APDE4DDYRK1AHRH3 | |
| SCHEMBL22464585 | 1.00 | EGFR (0.50) | EGFRKDM1APDE4DDYRK1AHRH3 | |
| SCHEMBL16374375 | 1.00 | EGFR (0.50) | EGFRKDM1APDE4DDYRK1AHRH3 | |
| SCHEMBL23578784 | 0.91 | EGFR (0.44) | EGFRKDM1APDE4DDYRK1AHRH3 | |
| SCHEMBL29959233 | 0.91 | EGFR (0.44) | EGFRKDM1APDE4DDYRK1AHRH3 | |
| SCHEMBL30848738 | 0.91 | EGFR (0.44) | EGFRKDM1APDE4DDYRK1AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3181564-B1 | AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS | HOFFMANN LA ROCHE (CH) | 2019-09-18 | — | — | EP | disclosed |
| EP-2922851-B1 | AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS | GENENTECH INC (US) | 2017-07-26 | — | — | EP | disclosed |
| EP-3181564-A1 | AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS | Genentech, Inc. (US) | 2017-06-21 | — | — | EP | disclosed |