Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 8/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2492915 | 1.00 | PTGDR2 (0.49) | PTGDR2EPHX2SIGMAR1HRH1HTR6 | |
| SCHEMBL1903098 | 1.00 | PTGDR2 (0.49) | PTGDR2EPHX2SIGMAR1HRH1HTR6 | |
| SCHEMBL1903248 | 0.93 | PTGDR2 (0.47) | PTGDR2HRH1HTR6MTNR1AMTNR1B | |
| SCHEMBL1899679 | 0.93 | PTGDR2 (0.47) | PTGDR2HRH1HTR6MTNR1AMTNR1B | |
| SCHEMBL1899681 | 0.93 | PTGDR2 (0.47) | PTGDR2HRH1HTR6MTNR1AMTNR1B | |
| SCHEMBL1898557 | 0.91 | PTGDR2 (0.51) | PTGDR2SIGMAR1HTR6CCR3 | |
| SCHEMBL1898556 | 0.91 | PTGDR2 (0.51) | PTGDR2SIGMAR1HTR6CCR3 | |
| SCHEMBL1900499 | 0.91 | PTGDR2 (0.51) | PTGDR2SIGMAR1HTR6CCR3 | |
| SCHEMBL1903879 | 0.91 | PTGDR2 (0.56) | PTGDR2SIGMAR1CCR3 | |
| SCHEMBL2488120 | 0.90 | PTGDR2 (0.50) | PTGDR2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051962-B1 | (3-AMINO-1,2,3,4-TETRAHYDRO-9H-CARBAZOL-9-YL)-ACETIC ACID DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2011-10-26 | — | — | EP | disclosed |
| EP-2316824-A1 | (3-Amino-1,2,3,4-tetrahydro-9H-carbazoI-9-yl)-acetic acid derivates | Actelion Pharmaceuticals Ltd. (CH) | 2011-05-04 | — | — | EP | disclosed |